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Hot Melt Extrusion: A Paradigm–Changing Technology
Recent Advances in Drug Delivery and Formulation, 2023Abstract: Over the last few decades, hot melt extrusion (HME) has found extensive adaptability and utility as a viable drug delivery option in the pharmaceutical industry. HME has already been validated as a robust, novel technique mainly used for the correction of solubility and bioavailability of poorly soluble drugs.
Vaibhav G. Bhamare, Ravindra K. Kamble
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Pharmaceutical Applications of Hot-Melt Extrusion: Part II
Drug Development and Industrial Pharmacy, 2007Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare ...
Michael A Repka +2 more
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Hot melt extrusion versus spray drying: hot melt extrusion degrades albendazole
Drug Development and Industrial Pharmacy, 2016The purpose of this study was to enhance the dissolution properties of albendazole (ABZ) by the use of amorphous solid dispersions. Phase diagrams of ABZ-polymer binary mixtures generated from Flory-Huggins theory were used to assess miscibility and processability.
Soraya, Hengsawas Surasarang +5 more
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Hot-melt extrusion of sugar-starch-pellets
International Journal of Pharmaceutics, 2015Sugar-starch-pellets (syn. sugar spheres) are usually manufactured through fluidized bed granulation or wet extrusion techniques. This paper introduces hot-melt extrusion (HME) as an alternative method to manufacture sugar-starch-pellets. A twin-screw extruder coupled with a Leistritz Micro Pelletizer (LMP) cutting machine was utilized for the ...
Chi-Wah, Yeung, Hubert, Rein
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Hot-melt Extrusion Technology and Pharmaceutical Application
Therapeutic Delivery, 2012The use of hot-melt extrusion (HME) within the pharmaceutical industry is steadily increasing, due to its proven ability to efficiently manufacture novel products. The process has been utilized readily in the plastics industry for over a century and has been used to manufacture medical devices for several decades.
Wilson, M. +3 more
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Continuous Processing of Micropellets via Hot-Melt Extrusion
AAPS PharmSciTech, 2022Microparticulate drug delivery systems, e.g., micropellets (MPs), are used in a variety of pharmaceutical formulations such as suspensions, injectable systems, and capsules. MPs are currently manufactured mainly via batch, solvent-based processes, e.g., spray-drying and solvent evaporation-extraction.
Martin Spoerk +7 more
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Cocrystalization and Simultaneous Agglomeration Using Hot Melt Extrusion
Pharmaceutical Research, 2010To explore hot melt extrusion (HME) as a scalable, solvent-free, continuous technology to design cocrystals in agglomerated form.Cocrystal agglomerates of ibuprofen and nicotinamide in 1:1 ratio were produced using HME at different barrel temperature profiles, screw speeds, and screw configurations.
Dhumal, Ravindra S. +4 more
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Hot Melt Extrusion Technique-A Review
Research Journal of Science and Technology, 2016Hot Melt Extrusion (HME) is well known process for the Plastic Industries but it is well accepted by the pharmaceutical industries for the last three decays. With the use of HME we can increase solubility and bio-availability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and ...
Bhushan A. Bhairav +2 more
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Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2012
Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism.
Salandová, Jana, Rabišková, Miloslava
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Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism.
Salandová, Jana, Rabišková, Miloslava
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Residence time modeling of hot melt extrusion processes
European Journal of Pharmaceutics and Biopharmaceutics, 2013The hot melt extrusion process is a widespread technique to mix viscous melts. The residence time of material in the process frequently determines the product properties. An experimental setup and a corresponding mathematical model were developed to evaluate residence time and residence time distribution in twin screw extrusion processes. The extrusion
Elena, Reitz +3 more
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