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Hot-Melt Extrusion for Enhanced Delivery of Drug Particles
Journal of Pharmaceutical Sciences, 2007With the recent advent of nanotechnology for pharmaceutical applications, drug particle engineering is the focus of increasing interest as a viable approach for overcoming solubility limitations of poorly water-soluble drugs. Although these particle engineering techniques have been proven successful for enhancing the dissolution properties of many ...
Dave A, Miller +4 more
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Preparation of starch-based pellets by hot-melt extrusion
European Journal of Pharmaceutics and Biopharmaceutics, 2011Spherical starch pellets were directly and continuously produced using hot-melt extrusion and die-face pelletisation. In contrast to conventional pelletisation procedures, a discontinuous spheronisation step can be dropped. Pellets were produced based on four different starches (corn starch, pea starch, potato starch and waxy corn starch), four ...
Sebastian, Bialleck, Hubert, Rein
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Review on Hot Melt Extrusion Technology and it
2019The use of hot-melt extrusion (HME) within the pharmaceutical industry is steadily increasing, due to proven its ability to efficiently manufacture novel products. With the use of HME we can increase solubility and bioavailability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and ...
S., Mali A. +4 more
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Hot-Melt Extrusion Technique: A Review
2004Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and ...
Chokshi, R, Zia, H
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Hot-melt extrusion microencapsulation of quercetin for taste-masking
Journal of Microencapsulation, 2017Besides its poor dissolution rate, the bitterness of quercetin also poses a challenge for further development. Using carnauba wax, shellac or zein as the shell-forming excipient, this work aimed to microencapsulate quercetin by hot-melt extrusion for taste-masking.
Chia Miang, Khor +4 more
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Hot-melt extrusion – basic principles and pharmaceutical applications
Drug Development and Industrial Pharmacy, 2014Originally adapted from the plastics industry, the use of hot-melt extrusion has gained favor in drug delivery applications both in academia and the pharmaceutical industry. Several commercial products made by hot-melt extrusion have been approved by the FDA, demonstrating its commercial feasibility for pharmaceutical processing.
Bo, Lang +2 more
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Application of rheology to hot melt extrusion: Theory and practice
International Journal of PharmaceuticsHot melt extrusion (HME) has become a key manufacturing method in the pharmaceutical industry for developing novel drug delivery systems, due to its solvent-free nature, ease of operation, and ability to achieve one-step molding and continuous processing.
Yisen, Wang +7 more
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Hot Melt Extrusion of Acrylic Films
Pharmaceutical Research, 1996C, Aitken-Nichol +2 more
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