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Hot-Melt Extrusion for Enhanced Delivery of Drug Particles
Journal of Pharmaceutical Sciences, 2007With the recent advent of nanotechnology for pharmaceutical applications, drug particle engineering is the focus of increasing interest as a viable approach for overcoming solubility limitations of poorly water-soluble drugs. Although these particle engineering techniques have been proven successful for enhancing the dissolution properties of many ...
Dave A, Miller +4 more
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800 mg Darunavir tablets prepared by hot melt extrusion
Pharmaceutical Development and Technology, 2010Darunavir (TMC 114) is a protease inhibitor used in the therapy of HIV-1. The aim of this study was to formulate 800 mg of Darunavir in a single unit dosage form, with suitable mechanical properties and dissolution behavior, using a corotating twin screw extruder.
Markus, Thommes +2 more
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Hot-melt extrusion microencapsulation of quercetin for taste-masking
Journal of Microencapsulation, 2017Besides its poor dissolution rate, the bitterness of quercetin also poses a challenge for further development. Using carnauba wax, shellac or zein as the shell-forming excipient, this work aimed to microencapsulate quercetin by hot-melt extrusion for taste-masking.
Chia Miang, Khor +4 more
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Understanding Hot Melt Extrusion via near Infrared Spectroscopy
NIR news, 2014The use of hot melt extrusion (HME) to produce pharmaceutical solid dispersions utilises pharmaceutical grade polymer(s), potentially high temperatures and mechanical energy to convert a drug substance from a crystalline to an amorphous state. Process analytical technology (PAT), in general, provides numerous manufacturing advantages but those ...
Brandye Smith-Goettler +2 more
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Basics of Compounding: Hot Melt Extrusion.
International journal of pharmaceutical compounding, 2018Hot Melt Extrusion, a production process that has been around for quite some time, has the ability to produce innovative compounds not previously achievable with conventional methods. However, many variables need to be considered prior to production.
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Hot-Melt Extrusion: The Process-Product-Performance Interplay
2014Hot-melt extrusion is commonly used to manufacture amorphous solid dispersions. This chapter focuses on the process-formulation-performance interplay of a hot-melt-extruded product within the framework of a hypothetical phase diagram. Special attention is paid to the liquidous curve and melt mixing, the mixed-phase glass transition temperature, and ...
Nathan Boersen +6 more
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Hot Melt Extrusion of Acrylic Films
Pharmaceutical Research, 1996C, Aitken-Nichol +2 more
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Hot-melt extrusion: a versatile technology
2021Mohammed Maniruzzaman, Jaywant Pawar
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Devices and Implants Prepared Using Hot Melt Extrusion
2013The development of medical devices (MD) and implants presents unique challenges and requirements not seen in the development of oral solid dosage forms. Through the use of hot melt extrusion (HME), it is possible to engineer novel systems capable of achieving specific geometries and release characteristics that enable the therapy. With extrusion, it is
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