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Hot-melt Extrusion Technology and Pharmaceutical Application
Therapeutic Delivery, 2012The use of hot-melt extrusion (HME) within the pharmaceutical industry is steadily increasing, due to its proven ability to efficiently manufacture novel products. The process has been utilized readily in the plastics industry for over a century and has been used to manufacture medical devices for several decades.
Wilson, M. +3 more
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Cocrystalization and Simultaneous Agglomeration Using Hot Melt Extrusion
Pharmaceutical Research, 2010To explore hot melt extrusion (HME) as a scalable, solvent-free, continuous technology to design cocrystals in agglomerated form.Cocrystal agglomerates of ibuprofen and nicotinamide in 1:1 ratio were produced using HME at different barrel temperature profiles, screw speeds, and screw configurations.
Dhumal, Ravindra S. +4 more
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Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti, 2012
Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism.
Salandová, Jana, Rabišková, Miloslava
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Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism.
Salandová, Jana, Rabišková, Miloslava
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Hot Melt Extrusion Technique-A Review
Research Journal of Science and Technology, 2016Hot Melt Extrusion (HME) is well known process for the Plastic Industries but it is well accepted by the pharmaceutical industries for the last three decays. With the use of HME we can increase solubility and bio-availability of the API. HME has proven to be a robust method of producing numerous drug delivery systems like modified, controlled and ...
Bhushan A. Bhairav +2 more
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Residence time modeling of hot melt extrusion processes
European Journal of Pharmaceutics and Biopharmaceutics, 2013The hot melt extrusion process is a widespread technique to mix viscous melts. The residence time of material in the process frequently determines the product properties. An experimental setup and a corresponding mathematical model were developed to evaluate residence time and residence time distribution in twin screw extrusion processes. The extrusion
Elena, Reitz +3 more
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Hot-Melt Extrusion for Enhanced Delivery of Drug Particles
Journal of Pharmaceutical Sciences, 2007With the recent advent of nanotechnology for pharmaceutical applications, drug particle engineering is the focus of increasing interest as a viable approach for overcoming solubility limitations of poorly water-soluble drugs. Although these particle engineering techniques have been proven successful for enhancing the dissolution properties of many ...
Dave A, Miller +4 more
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Hot-melt extrusion microencapsulation of quercetin for taste-masking
Journal of Microencapsulation, 2017Besides its poor dissolution rate, the bitterness of quercetin also poses a challenge for further development. Using carnauba wax, shellac or zein as the shell-forming excipient, this work aimed to microencapsulate quercetin by hot-melt extrusion for taste-masking.
Chia Miang, Khor +4 more
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Preparation of starch-based pellets by hot-melt extrusion
European Journal of Pharmaceutics and Biopharmaceutics, 2011Spherical starch pellets were directly and continuously produced using hot-melt extrusion and die-face pelletisation. In contrast to conventional pelletisation procedures, a discontinuous spheronisation step can be dropped. Pellets were produced based on four different starches (corn starch, pea starch, potato starch and waxy corn starch), four ...
Sebastian, Bialleck, Hubert, Rein
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Hot-melt extrusion – basic principles and pharmaceutical applications
Drug Development and Industrial Pharmacy, 2014Originally adapted from the plastics industry, the use of hot-melt extrusion has gained favor in drug delivery applications both in academia and the pharmaceutical industry. Several commercial products made by hot-melt extrusion have been approved by the FDA, demonstrating its commercial feasibility for pharmaceutical processing.
Bo, Lang +2 more
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Hot-Melt Extrusion Technique: A Review
2004Hot-melt extrusion is one of the most widely applied processing technologies in the plastic, rubber and food industry. Today this technology has found its place in the array of pharmaceutical manufacturing operations. Melt extrusion process are currently applied in the pharmaceutical field for the manufacture of a variety of dosage forms and ...
Chokshi, R, Zia, H
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