Results 201 to 210 of about 6,327 (248)
Formulation Development of Solid Self-Nanoemulsifying Drug Delivery Systems of Quetiapine Fumarate via Hot-Melt Extrusion Technology: Optimization Using Central Composite Design. [PDF]
PharmaceuticsUttreja P +8 more
europepmc +1 more source
Applications of hot-melt extrusion for drug delivery [PDF]
Expert Opinion on Drug Delivery, 2008 In today's pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade hot-melt extrusion (HME) has emerged as a powerful processing technology for drug delivery and has opened the door to a host of molecules previously ...
Michael A Repka +2 more
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Hot-Melt Extrusion: a Roadmap for Product Development
AAPS PharmSciTech, 2021Hot-melt extrusion has found extensive application as a feasible pharmaceutical technological option over recent years. HME applications include solubility enhancement, taste masking, and sustained drug release. As bioavailability enhancement is a hot topic of today's science, one of the main applications of HME is centered on amorphous solid ...
Marta F, Simões +2 more
openaire +2 more sources
Pharmaceutical Applications of Hot-Melt Extrusion: Part II
Drug Development and Industrial Pharmacy, 2007Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied technique in the plastics industry and has been demonstrated recently to be a viable method to prepare ...
Michael A Repka +2 more
exaly +4 more sources
Hot Melt Extrusion: A Paradigm–Changing Technology
Recent Advances in Drug Delivery and Formulation, 2023Abstract: Over the last few decades, hot melt extrusion (HME) has found extensive adaptability and utility as a viable drug delivery option in the pharmaceutical industry. HME has already been validated as a robust, novel technique mainly used for the correction of solubility and bioavailability of poorly soluble drugs.
Vaibhav G. Bhamare, Ravindra K. Kamble
openaire +2 more sources
Hot melt extrusion versus spray drying: hot melt extrusion degrades albendazole
Drug Development and Industrial Pharmacy, 2016The purpose of this study was to enhance the dissolution properties of albendazole (ABZ) by the use of amorphous solid dispersions. Phase diagrams of ABZ-polymer binary mixtures generated from Flory-Huggins theory were used to assess miscibility and processability.
Soraya, Hengsawas Surasarang +5 more
openaire +2 more sources
Continuous Processing of Micropellets via Hot-Melt Extrusion
AAPS PharmSciTech, 2022Microparticulate drug delivery systems, e.g., micropellets (MPs), are used in a variety of pharmaceutical formulations such as suspensions, injectable systems, and capsules. MPs are currently manufactured mainly via batch, solvent-based processes, e.g., spray-drying and solvent evaporation-extraction.
Martin Spoerk +7 more
openaire +2 more sources
Hot-melt extrusion of sugar-starch-pellets
International Journal of Pharmaceutics, 2015Sugar-starch-pellets (syn. sugar spheres) are usually manufactured through fluidized bed granulation or wet extrusion techniques. This paper introduces hot-melt extrusion (HME) as an alternative method to manufacture sugar-starch-pellets. A twin-screw extruder coupled with a Leistritz Micro Pelletizer (LMP) cutting machine was utilized for the ...
Chi-Wah, Yeung, Hubert, Rein
openaire +2 more sources