Results 251 to 260 of about 8,192,878 (290)
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Detection of antagonist activity for narcotic analgesics in mouse hot-plate test
Pharmacology Biochemistry and Behavior, 1979On the assumption that by the use of the hot-plate procedure the antagonist properties of narcotic analgesics could be detected, the effect of morphine, pentazocine, nalorphine and naloxone were investigated. The latency of paw-licking and jumping-off were determined and compared. The agonist, morphine, at doses of 0.025, 0.05 and 0.1 mmole/kg injected
P, Janicki, J, Libich
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European Journal of Pharmacology, 1972
Abstract Tolerance to the analgesic effect of morphine was studied using a 3 ft square hot plate to measure effect. Rats received saline, 2 ml/kg, s.c., or 5 or 10 mg/kg morphine, s.c., once weekly or once daily, respectively. They were randomly divided into major groups: tested with cylinder, tested without cylinder, ambient temperature tested with ...
G F, Gebhart, C L, Mitchell
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Abstract Tolerance to the analgesic effect of morphine was studied using a 3 ft square hot plate to measure effect. Rats received saline, 2 ml/kg, s.c., or 5 or 10 mg/kg morphine, s.c., once weekly or once daily, respectively. They were randomly divided into major groups: tested with cylinder, tested without cylinder, ambient temperature tested with ...
G F, Gebhart, C L, Mitchell
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Psychopharmacologia, 1971
The influence of “learning” on the development of tolerance to the analgesic effect of morphine in rats was examined employing the hot plate procedure. A tested-reinforced (Tr) group and its yoked-control, a tested-non-reinforced (Tnr) group, received identical exposure to the testing procedure; the Tr group was reinforced daily for its behavior on the
G F, Gebhart +2 more
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The influence of “learning” on the development of tolerance to the analgesic effect of morphine in rats was examined employing the hot plate procedure. A tested-reinforced (Tr) group and its yoked-control, a tested-non-reinforced (Tnr) group, received identical exposure to the testing procedure; the Tr group was reinforced daily for its behavior on the
G F, Gebhart +2 more
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Laboratory Animals, 2016
Researchers performing experiments on animals should always strive towards the refinement of experiments, minimization of stress and provision of better animal welfare. An adequate analgesic strategy is important to improve post-operative recovery and welfare in laboratory rats and mice.
Kristensen, Sara Hestehave +3 more
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Researchers performing experiments on animals should always strive towards the refinement of experiments, minimization of stress and provision of better animal welfare. An adequate analgesic strategy is important to improve post-operative recovery and welfare in laboratory rats and mice.
Kristensen, Sara Hestehave +3 more
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Associative tolerance to nicotine analgesia in the rat: Tail-flick and hot-plate tests.
Experimental and Clinical Psychopharmacology, 1998Previous assessments of associative nicotine tolerance may have confounded associative effects with novelty-induced stress effects, instrumental learning effects, or both. That is, subjects were tested in novel environments, allowed to practice the test response, or both during the tolerance development phase. In the first study, 32 male Sprague-Dawley
A, Cepeda-Benito +2 more
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Assessment of the Analgesic Effect of Centhaquin in Mouse Tail Flick and Hot-Plate Tests
Pharmacology, 2011<i>Background:</i> Centhaquin is a centrally acting hypotensive drug like clonidine. Clonidine also produces analgesia and hypothermia in mice and potentiates morphine analgesia. Clonidine analgesia is blocked by idazoxan and naloxone while it is potentiated by BQ123 and sulfisoxazole. This study was conducted to determine the analgesic and
Shridhar V, Andurkar, Anil, Gulati
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Male rats classified as copulators and noncopulators respond differentially on the hot plate test
Physiology & Behavior, 1993Sexually naive male rats that fail to copulate with a sexually receptive female (noncopulators) have been shown to be less responsive to a variety of environmental stimuli in comparison to rats that do engage in copulation (copulators). In this experiment, it was found that noncopulators were less responsive than copulators to noxious thermal ...
J, Rochford, S, Chatigny
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Pharmacological Reports, 2009
This study was aimed at determining the analgesic effect of gabapentin and tiagabine, two antiepileptic drugs that were administered alone and in combination at a fixed ratio of 1:1, in the acute thermal pain model (hot-plate test) in mice. Linear regression analysis was used to evaluate the dose-response relationships between logarithms of ...
Jarogniew J, Luszczki +5 more
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This study was aimed at determining the analgesic effect of gabapentin and tiagabine, two antiepileptic drugs that were administered alone and in combination at a fixed ratio of 1:1, in the acute thermal pain model (hot-plate test) in mice. Linear regression analysis was used to evaluate the dose-response relationships between logarithms of ...
Jarogniew J, Luszczki +5 more
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Psychopharmacology, 1994
The objectives of this study were: i) to analyse the effects of morphine and naloxone on the rat's behaviour in the hot plate test using an ethological approach, and ii) to compare the effectiveness of repeated versus single test paradigms. Animals received either morphine (0, 3, 6 or 9 mg/kg SC) or naloxone (0, 0.01, 0.1 or 1 mg/kg SC).
E F, Espejo, L, Stinus, M, Cador, D, Mir
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The objectives of this study were: i) to analyse the effects of morphine and naloxone on the rat's behaviour in the hot plate test using an ethological approach, and ii) to compare the effectiveness of repeated versus single test paradigms. Animals received either morphine (0, 3, 6 or 9 mg/kg SC) or naloxone (0, 0.01, 0.1 or 1 mg/kg SC).
E F, Espejo, L, Stinus, M, Cador, D, Mir
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Neuropharmacology, 1989
The data reported for the antinociceptive effect of tricyclic antidepressants are conflicting. In this investigation, the effect of acute intraperitoneal (i.p.) administration of desipramine (2 and 5 mg/kg) was studied in rats, using the tail-flick test with simultaneous measurement of tail-skin temperature, and the increasing temperature hot-plate ...
A, Lund, A, Tjølsen, K, Hole
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The data reported for the antinociceptive effect of tricyclic antidepressants are conflicting. In this investigation, the effect of acute intraperitoneal (i.p.) administration of desipramine (2 and 5 mg/kg) was studied in rats, using the tail-flick test with simultaneous measurement of tail-skin temperature, and the increasing temperature hot-plate ...
A, Lund, A, Tjølsen, K, Hole
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