Results 101 to 110 of about 2,727,731 (214)

Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects

Epigenetics & Chromatin, 2019
Background Neural tube defects (NTDs) are severe, common birth defects that result from failure of normal neural tube closure during early embryogenesis. Accumulating strong evidence indicates that genetic factors contribute to NTDs etiology, among them, 
Juan Yu, Lei Wang, Pei Pei, Xue Li, Jianxin Wu, Zhiyong Qiu, Juan Zhang, Ruifang Ao, Shan Wang, Ting Zhang, Jun Xie   +10 more
doaj   +1 more source

The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development

We report the isolation and expression pattern of a novel mouse homeobox gene, Hox-4.8. Hox-4.8 is the most 5'-located homeobox gene in the HOX-4 complex.
Izpisua-Belmonte, J. C., Boncinelli, E., Duboule, D., Dolle, P.   +3 more
core   +1 more source

A Hox class 3 orthologue from the spider Cupiennius salei is expressed in a Hox-gene like fashion

, 1998
The class 3 Hox gene orthologue in insects, zerknullt (zen), is not expressed along the anterior-posterior axis, but only in extra-embryonic tissues, suggesting that it has lost its function as a normal Hox gene.
Damen, W., Tautz, D. ; https://orcid.org/   +1 more
core   +1 more source

HOX Gene Aberrant Expression in Skin Melanoma: A Review

Journal of Skin Cancer, 2012
The homeobox family and its subset of HOX gene products represent a family of transcription factors directing DNA-protein and protein-protein interactions. In the embryo, they are central regulators in cell differentiation during morphogenesis.
Gérald E. Piérard, Claudine Piérard-Franchimont   +1 more
doaj   +1 more source

The significance of Hox gene collinearity

The International Journal of Developmental Biology, 2015
Arthropods and vertebrates inherited their Hox clusters from an ancestral cluster of at least six genes already present in their last common ancestor, Urbilateria. Clustering and a common transcriptional direction are both likely features of the way that the gene complex first arose in a process of tandem gene duplication.
openaire   +3 more sources

The urbilaterian Super-Hox cluster.

, 2008
Comparison of whole genome sequences of representative animals enables reconstruction of the ancestral bilaterian genome: the starting point from which most extant animal lineages evolved.
Butts, T, Holland, Peter W.H., Ferrier, David E.K., Butts, Thomas, Holland, PWH, Ferrier, David Ellard Keith, Ferrier, David Ellard Keith; id_orcid   +6 more
core   +1 more source

The murine genes Hox-5.1 and Hox-4.1 belong to the same HOX complex on chromosome 2

Two different loci of Antennapedia-related homeobox-containing genes have been shown to map to mouse chromosome 2: the HOX-5 complex and the Hox-4.1 gene.
Lehrach, H., Duboule, D., Lonai, P., Stubbs, L., Baron, A., Poustka, A.   +5 more
core   +1 more source

lazarus is a novel pbx gene that globally mediates hox gene function in zebrafish

, 2000
Individual vertebrate Hox genes specify aspects of segment identity along the anterior-posterior axis. The exquisite in vivo specificity of Hox proteins is thought to result from their interactions with members of the Pbx/Exd family of homeodomain ...
Pöpperl, H., Haffter, P., Kimmel, C., Chang, H., Rikhof, H., Moens, C.   +5 more
core   +1 more source

Primary structure and embryonic expression pattern of the mouse Hox-4,3 homeobox gene

, 1990
We report the cloning, genomic localization, primary structure and developmental expression pattern of the novel mouse Hox-4.3 gene. This gene is located within the HOX-4(5) complex, at a position which classifies it as a member of the Hox-3.1 and -2.4 ...
Falkenstein H., Izpisua-Belmonte J. -C., Dolle P., Duboule D., Renucci A., Zappavigna V.   +5 more
core  

Hox-5.1 defines a homeobox-containing gene locus on mouse chromosome 2

We have isolated a murine homeobox-containing gene, Hox-5.1, by virtue of its relatedness to the Hox-1.4 gene. In situ hybridization to metaphase spreads mapped Hox-5.1 to band D of mouse chromosome 2.
Mattei, M. G., Duboule, D., Gaunt, S. J., Baron, A., Featherstone, M. S.   +4 more
core   +1 more source