Results 111 to 120 of about 2,727,731 (214)

Akt1 as a putative regulator of Hox genes

, 2013
In mammals, precise spatiotemporal expressions of Hox genes control the main body axis during embryogenesis. However, the mechanism by which Hox genes are regulated is poorly understood. To discover the putative regulator of Hox genes, in silico analyses
공경아, 김명희
core   +1 more source

Hox-gene expression as a biomarker for igf-1r therapeutics

, 2008
This invention provides methods for treating or preventing the onset of a tumor in a subject, wherein the tumor is determined to overexpress a Hox gene, including administering to the subject a therapeutically or prophylactically effective amount of an ...
Whelan, Jarrett Thomas, Bertrand, Fred E.   +1 more
core   +1 more source

Hox Gene Loss during Dynamic Evolution of the Nematode Cluster.

, 2016
HOX GENES ARE IMPORTANT: their central role in anterior-posterior patterning provides a framework for molecular comparison of animal body plan evolution. The nematode Caenorhabditis elegans stands out as having a greatly reduced Hox gene complement.

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Analysis of the murine Hox-2.7 gene: Conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions

, 1992
In this study we have investigated the organization and regulation of the mouse Hox-2.7 gene. There are several alternative transcripts some of which are conserved between mouse and humans.
Sham, Mai Har, Hunt, P, Graham, Anthony, Nonchev, Stefan, Krumlauf, Robb, Nonchev, S, Boncinelli, E, Papalopulu, N, Boncinelli, Edoardo, Hunt, Paul, Graham, A, Sham, MH, Papalopulu, Nancy, Krumlauf, R   +13 more
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Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo. [PDF]

Nat Commun, 2022
Benetti N, Gouil Q, Tapia Del Fierro A, Beck T, Breslin K, Keniry A, McGlinn E, Blewitt ME.   +7 more
europepmc   +1 more source

Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. [PDF]

, 1991
journal articleGene targeting in mouse embryo-derived stem cells has been used to disrupt the homeobox gene hox-1.5. Mice heterozygous at the hox-1.5 locus appear normal, whereas hox-1.5-/hox-1.5- mice die at or shortly after birth. These homozygotes are
Chisaka, Osamu, Capecchi, Mario R.
core  

Distinct HOX Gene Family DNA Methylation Profiles in Histologically Normal Skin Dependent on Dermoscopic Pattern of Adjacent Nevi. [PDF]

J Invest Dermatol, 2023
Muse ME, Schaider H, Oey H, Soyer HP, Christensen BC, Stark MS.   +5 more
europepmc   +1 more source

Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. [PDF]

, 2002
journal articleGene targeting in mouse embryo-derived stem cells has been used to generate mice with a disruption in the homeobox gene Hox-1.6. Mice heterozygous at the Hox-1.6 locus appear normal, whereas Hox-1.6-/Hox-1.6- mice die at or shortly after ...
Chisaka, Osamu; Musci, Teresa S., Capecchi, Mario R.   +1 more
core  

The zebrafish homeobox gene Hox(zf-114): primary structure, expression pattern and evolutionary aspects

, 1992
It is gradually becoming accepted that vertebrate homeobox genes, like their counterparts in Drosophila, are crucial for normal development of the embryo.
Hordvik, Ivar, Njølstad, Pål Rasmus, Gheulue, M. van, Fjose, Anders, Molven, Anders   +4 more
core  

HOX-Gene Cluster Organization and Genome Duplications in Fishes and Mammals: Transcript Variant Distribution along the Anterior-Posterior Axis. [PDF]

Int J Mol Sci, 2022
Ozernyuk N, Schepetov D.
europepmc   +1 more source