Results 241 to 250 of about 23,630,409 (308)

ROS‐Responsive Nanoparticle Delivery of Dexmedetomidine Protects the Gut Vascular Barrier After Intestinal Ischemia/Reperfusion via the HDAC‐H3K27ac‐TCF4 Axis

Advanced Science, EarlyView.
A low dose of dexmedetomidine, delivered by ROS‐responsive nanoparticles, preferentially accumulates in the ischemic intestine and restores gut vascular barrier integrity after ischemia/reperfusion injury. This nanoparticle‐based strategy prevents bacterial translocation and liver damage without cardiorespiratory side effects, working through HDAC ...
Hu‐Fei Zhang, Jian‐Tong Shen, Hua‐Hua Zhang, Si‐Qi Gao, Ji‐Ao Wang, Yue‐Ling Wang, Mei‐Ling Li, Zi‐Meng Liu, Yi‐Nan Zhang, Yan Li, Xu‐Yu Zhang   +10 more
wiley   +1 more source

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

Advanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou, Fan Zhang, Jiangbo Wang, Huiyuan Wang, Zongqiang Wang, Qianqian Wang, Chuikai Meng, Jialu Sun, Han Wang, Weiye Li, Ziyi Zhao, Le Qi, Xiaosong Gu, Shusen Cui, Rangjuan Cao   +14 more
wiley   +1 more source

Design of a Novel Diamine Biosensor to Guide the Engineering of Escherichia coli for Cadaverine Overproduction

Advanced Science, EarlyView.
A high‐throughput screening platform was established by integrating an in vivo cadaverine biosensor with a fluorescence‐activated cell sorting (FACS) system. Biosensor‐driven specific exporter tuning, pathway optimization and genome‐wide target mining were conducted to maximize cadaverine production in Escherichia coli.
Jia Feng, Getao Liu, Ding Ma, Jiaxiang Yuan, Xinyi Zhang, Weihao Wang, Chen Ma, Yang Liao, Siyuan Gao, Lei Qin, Jiao Feng, Sheng Xu, Xin Wang, Kequan Chen   +13 more
wiley   +1 more source

Spatiotemporally Controlled Sequential Chemo‐Immunotherapy Activates Pyroptosis for Robust Anti‐Tumor Immunotherapy

Advanced Science, EarlyView.
A glutathione and ultrasound dual‐responsive cerasome achieves sequential co‐delivery of gemcitabine and BMS1166 in tumors. Chemotherapy priming followed by on‐demand PD‐L1 blockade synergistically amplifies anti‐tumor immunity, inhibiting primary tumor growth, distant metastasis and inducing durable immune memory.
Suhui Sun, Ruiqi Wu, Qingshuang Tang, Yunli Xu, Wanrui Shi, Mengxin Wang, Haonan Wang, Yan Luo, Cheng Ma, Xiaolong Liang   +9 more
wiley   +1 more source

HPLC Analysis

, 2013
HPLC analysis of (D) NP2; (E) OP1.
Serban C. Moldoveanu, Victor David
core   +3 more sources

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HPLC analysis of antioxidants

Talanta, 1990
Qualitative and quantitative HPLC methods are described for the analysis of mixtures of twelve antioxidants. For identification of the components present, gradient elution with a convex profile from 35:65 v/v water-methanol to pure methanol is used, on a Waters 5 mum C(18) Resolve column, with an ultraviolet detector.
C, Grosset, D, Cantin, A, Villet, J, Alary   +3 more
openaire   +2 more sources

Analysis of Xanthophylls in Corn by HPLC

Journal of Agricultural and Food Chemistry, 2002
An HPLC method was developed using the C-30 carotenoid column to separate and identify the major xanthophylls in corn (lutein, zeaxanthin, and beta-cryptoxanthin). A photodiode array detector and a mobile phase consisting of methyl tert-butyl ether/methanol/water was used. All three xanthophylls eluted in less than 25 min.
E E, Moros, D, Darnoko, M, Cheryan, E G, Perkins, J, Jerrell   +4 more
openaire   +2 more sources

HPLC Neurotransmitter Analysis

2016
High performance liquid chromatography (HPLC) is a powerful tool to measure neurotransmitter levels in specific tissue samples and dialysates from patients and animals. In this chapter, we list the current protocols used to measure neurotransmitters in the form of biogenic amines from murine brain samples.
Holm, Thomas Hellesøe, Isaksen, Toke Jost, Lykke-Hartmann, Karin; id_orcid 0000-0002-6702-183X   +2 more
openaire   +3 more sources

Analysis of the diastereoisomers of alliin by HPLC

Talanta, 2012
Garlic has been known for its therapeutic effects for centuries and is used worldwide as a functional food. The concentration of the active molecules could be enhanced by a better knowledge of their biosynthesis. The precursor of these compounds, alliin (a sulfur amino-acid) has been obtained by chemical synthesis.
DETHIER, Bérénice, Laloux, Morgan, Hanon, Emilien, Nott, Katherine, Heuskin, Stéphanie, Wathelet, Jean-Paul   +5 more
openaire   +2 more sources