Results 51 to 60 of about 9,143 (202)

Preparation, Characterization and Diagnostic Valuation of Two Novel Anti-HPV16 E7 Oncoprotein Monoclonal Antibodies

Viruses, 2020
At present, the clinical detection method of human papillomavirus (HPV) is mainly based on the PCR method. However, this method can only be used to detect HPV DNA and HPV types, and cannot be used to accurately predict cervical cancer.
Renjian Hu, Zhen Dong, Kui Zhang, Guangzhao Pan, Chongyang Li, Hongjuan Cui   +5 more
doaj   +1 more source

HPV16 mutations.

, 2018
(A) The percentage of HPV16 positive squamous cell carcinomas with mutant E6 protein is significantly higher in the oropharynx, than in the cervix. (B) Amino acid sequence of the HPV16 E6 protein. Mutation sites in OSCC are highlighted.
Susan M. Fennewald (5703743), Vicente A. Resto (349111), John H. Lee (334901), Suimin Qiu (151100), Dianne I. Lou (194248), Bailey A. LeConte (5703740), Peter Szaniszlo (349109), Nai-Wei Chen (5703746)   +7 more
core   +1 more source

Oral HPV16 DNA as a screening tool to detect early oropharyngeal squamous cell carcinoma

, 2020
Given that oropharyngeal squamous cell carcinoma (OPSCC) have now surpassed cervical cancer as the most common human papillomavirus (HPV)-driven cancer, there is an interest in developing non-invasive predictive biomarkers to early detect HPV-driven ...
Chamindie Punyadeera, Frazer, Ian H., Kenny, Liz, Punyadeera, Chamindie, Scheper, Gert C, Tang, Kai D, Sarju Vasani, Lilian Menezes, Liz Kenny, Kai D. Tang, Vasani, Sarju, Scheper, Gert C., Laurence J. Walsh, Ian H. Frazer, Hughes, Brett G.M., Frazer, Ian H, Menezes, Lilian, Hughes, Brett GM, Taheri, Touraj, Gert C. Scheper, Walsh, Laurence J., Touraj Taheri, Tang, Kai D., Brett G.M. Hughes, Walsh, Laurence J   +24 more
core   +1 more source

Distribution and Clinical Significance of HPV16 Variants in Head and Neck Squamous Cell Carcinomas: Data from a Portuguese Cohort and Systematic Review

, 2023
ReviewIntroduction: Genomic variants of the human papillomavirus type 16 (HPV16) are thought to play differential roles in the susceptibility to head and neck squamous cell carcinomas (HNSCC) and its biological behaviour.
Montalvão, Pedro, Félix, Ana, Gomes, João P., Martins, Luís, Vieira, Luis, Cunha, Mario, Cochicho, Daniela, Magalhães, Miguel, Sobral, Daniel, Gil da Costa, Rui M., Nunes, Alexandra, Mendonça, Joana, Esteves, Susana   +12 more
core   +1 more source

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 mice

Exploration of Medicine
Aim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A.
Beatriz Medeiros-Fonseca, Ana I. Faustino-Rocha, Jéssica Silva, Mónica G. Silva, Maria João Pires, Maria João Neuparth, Helena Vala, Cármen Vasconcelos-Nóbrega, Maria I. Dias, Lillian Barros, Lio Gonçalves, Isabel Gaivão, Margarida M. S. M. Bastos, Luís Félix, Carlos Venâncio, Rui Medeiros, Rui M. Gil da Costa, Paula A. Oliveira   +17 more
doaj   +1 more source

Integration of human papillomavirus 16 in esophageal carcinoma samples

Infectious Agents and Cancer, 2017
Background Esophageal carcinoma (EC) is one of the major cancers in China. In 1982, Syrjanen first hypothesized the relationship between human papillomavirus (HPV) infection and the development of esophageal cancer.
Shuying Li, Haie Shen, Zhanjun Liu, Ning Li, Suxian Yang, Ke Zhang, Jintao Li   +6 more
doaj   +1 more source

HPV16 L2_108–126 is exposed on HPV16 L1L2 VLP and HPV16 PsV.

, 2012
ELISA plate wells were coated with 500 ng of HPV16 L1 VLP, HPV16 L1L2 VLP or HPV16 PsV and subsequently incubated with anti-L1 H16.V5 or anti L2108–126 16L2.4B4 antibodies.
Heike E. Brand (140659), Ralf Langen (140663), Diane M. Da Silva (140651), W. Martin Kast (140664), J. Mario Isas (140661), Joseph G. Skeate (140653), Andrew W. Woodham (140650), Adam B. Raff (140655), Mark R. Ambroso (140657)   +8 more
core   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source

The Role of DCT in HPV16 Infection of HaCaTs

PLOS ONE, 2017
Persistent infection with high-risk human papillomavirus (HPV) genotype is a major factor leading to many human cancers. Mechanisms of HPV entry into host cells and genome trafficking towards the nucleus are incompletely understood. Dopachrome tautomerase (DCT) was identified as a cellular gene required for HPV infection in HeLa cells on a siRNA screen
Pınar Aksoy, Patricio I Meneses
openaire   +4 more sources