Results 31 to 40 of about 9,143 (202)

HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples

Tumour Virus Research, 2021
Human papillomavirus (HPV) 16 and 18 are the most predominant types in cervical cancer. Only a small fraction of HPV infections progress to cancer, indicating that additional factors and genomic events contribute to the carcinogenesis, such as minor ...
Sonja Lagström, Alexander Hesselberg Løvestad, Sinan Uğur Umu, Ole Herman Ambur, Mari Nygård, Trine B. Rounge, Irene Kraus Christiansen   +6 more
doaj   +1 more source

Interferon‐γ and IL‐5 associated cell‐mediated immune responses to HPV16 E2 and E6 distinguish between persistent oral HPV16 infections and noninfected mucosa

Clinical and Experimental Dental Research, 2021
Objectives Natural history of human papillomavirus (HPV) infection in the head and neck region is poorly understood, and their impact on collective HPV‐specific immunity is not known.
Anna Paaso, Hanna‐Mari Koskimaa, Marij J. P. Welters, Katja Kero, Jaana Rautava, Kari Syrjänen, Sjoerd H. van derBurg, Stina Syrjänen   +7 more
doaj   +1 more source

Immune Signature-Based Subtypes of Cervical Squamous Cell Carcinoma Tightly Associated with Human Papillomavirus Type 16 Expression, Molecular Features, and Clinical Outcome

Neoplasia: An International Journal for Oncology Research, 2019
Substantial heterogeneity exists within cervical cancer that is generally infected by human papillomavirus (HPV). However, the most common histological subtype of cervical cancer, cervical squamous cell carcinoma (CSCC), is poorly characterized regarding
Xiaofan Lu, Liyun Jiang, Liya Zhang, Yue Zhu, Wenjun Hu, Jiashuo Wang, Xinjia Ruan, Zhengbao Xu, Xiaowei Meng, Jun Gao, Xiaoping Su, Fangrong Yan   +11 more
doaj   +1 more source

ASSOCIATION OF HPV16 VIRAL LOAD IN GENE L2 WITH CANCER STAGES AND DEMOGRAPHIC CHARACTERISTICS IN CERVICAL CANCER PATIENTS FROM DHI-QAR PROVINCE, IRAQ

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2023
Background. Human papillomavirus (HPV) infection, especially high-risk HPV16, is a risk factor for cervical cancer. HPV16 genotype demographic variations may affect carcinogenicity.
А. Т. Джалил
doaj   +1 more source

HPV16 Impacts NHERF2 Expression in Oropharyngeal Cancers

Pathogens, 2023
Infection with human papillomaviruses (HPVs), in particular with HPV type 16, is now considered to be a key risk factor for the development of a subset of oropharyngeal squamous cell carcinomas (OPSCC) that show different epidemiological, clinical, and prognostic characteristics from HPV-negative (HPV−) OPSCCs. So far, extensive research efforts aiming
Lucija Lulić, Antonia Jakovčević, Iva Kovačić, Luka Manojlović, Emil Dediol, Josipa Skelin, Vjekoslav Tomaić   +6 more
openaire   +5 more sources

Thermostable Bioluminescent Intercalating Dyes for Real‐Time, Integrated Nucleic Acid Amplification and Detection

Angewandte Chemie, EarlyView.
We present a bioluminescent diagnostic platform that integrates DNA amplification and detection in a single step. The engineering of thermostable luciferase‐intercalating dye conjugates and controlled release of caged luciferin substrates enable real‐time, detection of attomolar concentrations of viral DNA within 30 min.
Yosta de Stigter, Harmen J. van der Veer, Sterre de Lignie, Robbert J. de Haas, Renko de Vries, Joost P. H. Schoeber, Anne J. M. Loonen, Adriaan J. C. van den Brule, Maarten Merkx   +8 more
wiley   +2 more sources

Evidence-based guideline diagnosis, treatment, prevention and aftercare of oropharyngeal and hypopharyngeal carcinoma

GMS German Medical Science
The guideline is being drawn up as a joint guideline for oropharyngeal and hypopharyngeal carcinoma. Oropharyngeal carcinoma in particular has experienced the greatest increase in incidence among all head and neck carcinomas in the last 20 years and is ...
Dietz, Andreas, Taylor, Kathy, Bayer, Oliver, Singer, Susanne, Follmann, Markus, Nothacker, Monika, Langer, Thomas, Klussmann, Peter, Lang, Stephan, Hoffmann, Thomas, Maschmeyer, Georg, Wiegand, Susanne, Fuchs, Michael, Weichert, Wilko, Heß, Jochen, Guntinas-Lichius, Orlando, Waterboer, Tim, Lell, Michael, Büntzel, Jens, Balermpas, Panagiotis, Schmidt, Kerstin, Steingräber, Maria, Klautke, Gunther, Hellmund, Herbert, Kissinger, Gunthard, Brossart, Peter, Maatouk, Imad, Lethaus, Bernd, Raguse, Jan, Zöphel, Klaus, Lippach, Kristina, Sterr, Fritz, Christiansen, Hans, Duncker, Christian, Keilmann, Annerose, Cici, Havva, Yzer, Jutta, Relic, Alessandro, Paradies, Kerstin, Budach, Wilfried   +39 more
doaj   +1 more source

SAMHD1 Regulates Human Papillomavirus 16-Induced Cell Proliferation and Viral Replication during Differentiation of Keratinocytes

mSphere, 2019
Human papillomaviruses induce a host of anogenital cancers, as well as oropharyngeal cancer (HPV+OPC); human papillomavirus 16 (HPV16) is causative in around 90% of HPV+OPC cases.
Claire D. James, Apurva T. Prabhakar, Raymonde Otoa, Michael R. Evans, Xu Wang, Molly L. Bristol, Kun Zhang, Renfeng Li, Iain M. Morgan   +8 more
doaj   +1 more source

Association between oncogenic human papillomavirus type 16 and Killian polyp

Infectious Agents and Cancer, 2021
Background Killian polyp (KP) is a benign lesion that arises from the maxillary sinus. The etiology of KP is unknown. The aim of this study was to investigate the potential involvement of human papilloma- (HPV) and polyoma-viruses (HPyV) infections in ...
Lucia Oton-Gonzalez, John Charles Rotondo, Luca Cerritelli, Nicola Malagutti, Carmen Lanzillotti, Ilaria Bononi, Andrea Ciorba, Chiara Bianchini, Chiara Mazziotta, Monica De Mattei, Stefano Pelucchi, Mauro Tognon, Fernanda Martini   +12 more
doaj   +1 more source

A novel HPV16 E7-affitoxin for targeted therapy of HPV16-induced human cervical cancer

Theranostics, 2018
Cervical cancer, the second most common cause of cancer death in women worldwide, is significantly associated with infection of high-risk human papillomaviruses (HPVs), especially the most common genotype, HPV 16. To date, there is no established noninvasive therapy to treat cervical cancer. Methods: Here, we report a novel affitoxin that targets HPV16
Jiang, Pengfei, Wang, Lude, Hou, Bailong, Zhu, Jinshun, Zhou, Meng, Jiang, Jie, Wang, Ledan, Chen, Shao, Zhu, Shanli, Chen, Jun, Zhang, Lifang   +10 more
openaire   +2 more sources