Results 41 to 50 of about 9,143 (202)

DisV-HPV16, versatile and powerful software to detect HPV in RNA sequencing data

BMC Infectious Diseases, 2019
Background The increasing availability of high-throughput sequencing data provides researchers with unprecedented opportunities to investigate viral genetic elements in host genomes that contribute to virus-linked cancers.
Bingqing Yan, Xinyi Liu, Siwei Zhang, Siyang Yu, Fangjia Tong, Huanhuan Xie, Lianhao Song, Yan Zhang, Lanlan Wei   +8 more
doaj   +1 more source

Correlation between HPV16 positivity on anal swab and biopsy-confirmed HSIL caused by HPV16 in the study of the prevention of anal cancer (SPANC)

Papillomavirus Research, 2018
Background: The majority of anal carcinomas are caused by human papillomavirus (HPV) 16. Identifying which of the high-grade squamous intraepithelial lesions (HSIL) are caused by HPV16 may enable targeted management of those most likely to progress ...
Jennifer M. Roberts, Monica Molano, Julia K. Thurloe, Richard J. Hillman, David J. Templeton, Carmella Law, I. Mary Poynten, Fengyi Jin, Patricia Guzman, Suzanne M. Garland, Dorothy A. Machalek, Andrew E. Grulich, Alyssa M. Cornall   +12 more
doaj   +1 more source

Human papillomavirus 16 non-European variants are preferentially associated with high-grade cervical lesions. [PDF]

PLoS ONE, 2014
HPV16 accounts for 50-70% of cervical cancer cases worldwide. Characterization of HPV16 variants previously indicated that they differ in risks for viral persistence, progression to cervical precancer and malignant cancer.
Luciana Bueno Freitas, Zigui Chen, Elaine Freire Muqui, Neide Aparecida Tosato Boldrini, Angélica Espinosa Miranda, Liliana Cruz Spano, Robert D Burk   +6 more
doaj   +1 more source

HPV-16 E7-Specific Cellular Immune Response in Women With Cervical Intraepithelial Lesion Contributes to Viral Clearance: A Cross-Sectional and Longitudinal Clinical Study

Frontiers in Immunology, 2022
High-risk human papillomavirus (HPV) infection is the cause of almost all cervical cancers. HPV16 is one of the main risk subtypes. Although screening programs have greatly reduced the prevalence of cervical cancer in developed countries, current ...
Lina Zhang, Xinyi Shi, Qing Zhang, Zhilei Mao, Xiaoyu Shi, Jun Zhou, Aili Jian, Aili Jian, Renying Zhu, Shisong Jiang, Wenshu Lu, Wenshu Lu, Wenshu Lu   +12 more
doaj   +1 more source

HPV16 E6 upregulates Aurora A expression

Oncology Letters, 2016
Overexpression of Aurora A kinase occurs in certain types of cancer, and therefore results in chromosome instability and phosphorylation-mediated ubiquitylation and degradation of p53 for tumorigenesis. The high-risk subtype human papillomavirus (HPV)16 early oncoprotein E6 is a major contributor inducing host cell immortalization and transformation ...
Guo, Yi, Ma, Jiaming, Zheng, Yahong, Li, Lu, Gui, Xiaowei, Wang, Qian, Meng, Xiangkai, Shang, Hong   +7 more
openaire   +3 more sources

A Critical Role for p53 during the HPV16 Life Cycle

Microbiology Spectrum, 2022
Human papillomaviruses (HPV) are causative agents in ano-genital and oral cancers; HPV16 is the most prevalent type detected in human cancers. The HPV16 E6 protein targets p53 for proteasomal degradation to facilitate proliferation of the HPV16 infected ...
Christian T. Fontan, Claire D. James, Apurva T. Prabhakar, Molly L. Bristol, Raymonde Otoa, Xu Wang, Elmira Karimi, Pavithra Rajagopalan, Devraj Basu, Iain M. Morgan   +9 more
doaj   +1 more source

HPV16-positive cervical cancer lesions contain less IRF6 and IL-1β.

, 2018
(A) Immunofluorescence of normal cervical issue and HPV16+ cervical cancer biopsies. IL-1β (green), p53 (red) with trace indicating the basal layer and nucleus (white). Normal (HPV−) and a neoplastic biopsy (HPV16+) from one representative patient out of
Claudia Zannetti (199411), Massimo Tommasino (8382), Issam Tout (5614325), Alexis Robitaille (4760709), Katia Zanier (17371), Uzma Ayesha Hasan (5614346), François Briat (5614328), Philip Auron (5614334), Pauline Rochefort (5614316), Alexandra Traverse-Glehen (670554), Guillaume Roblot (5614322), Nadege Goutagny (271017), Christine Carreira (385304), Michelle Ainouze (4025969), Peggy Parroche (5614319), Francois Golfier (5614340), Thierry Walzer (48278), Thomas Henry (363323), Aude Lunel-Potencier (5614337), Murielle Masson (198518), Gilles Trave (5614343), Marie Marotel (5614331)   +21 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Pooled analysis of HPV infection in paired anal and cervical samples, by HIV status

Papillomavirus Research, 2018
Background: In light of HPV16's unique carcinogenicity in the anus, knowledge of anal HPV16 prevalence may be a useful surrogate for stratifying groups of women at differing anal cancer risk based on routinely available cervical cancer screening outcomes.
Gary Clifford, IARC HPV study group.
doaj   +1 more source