Results 91 to 100 of about 3,624 (150)

Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation

Advanced Science
Proteotoxicity induced by misfolded or aggregated proteins causes progressive neuronal damage. The endoplasmic reticulum (ER) protein quality control (ERQC) pathways are responsible for mitigating the accumulation of these misfolded or aggregated ...
Xuya Pan, Xing He, Su Wu, Na Xiong, Xinyu Hou, Heting Wang, Diane Somlo, Martin Spiess, Haiyang Wang, Jifeng Yang, Chunliang Li, Shasha Li, Wenbin Ma, Yanming Chen, Jun Cui, Ling Qi, Guojun Shi   +16 more
doaj   +1 more source

In vitro ubiquitylation assay of PfHRD1 (PF14_0215).

, 2012
(A) Epitope-tagged recombinant PfHRD1 was expressed in E. coli and purified. Anti-GST immunoblot on purified protein extracts reveals the presence of detached free GST tags (MW = 29 kDa) and of PfHRD1-GST (MW = 42.6 kDa).
Karine G. Le Roch (45423), Nadia Ponts (48033), Jacques Prudhomme (48031), Elisandra M. Rodrigues (142799), Duk-Won D. Chung (142793)   +4 more
core   +1 more source

CSFV NS5B interacts with HRD1 and inhibits ubiquitination of METTL14.

(A) PK-15 cells transfected with pFlag-NS5B were treated with MG132 (10 μM) for indicated times and then harvested for western blotting by using rabbit anti-METTL14 antibody, mouse anti-Flag antibody, and β-actin as a loading control.
Bing-qian Zhao (18275791), Xiao-han Li (12578525), Bin Zhou (84959), Ji-shan Bai (18275788), Jia-huan Hu (12047433), Hui-xin Song (18275785), Rui-cong Sun (12047436), Mei-zhen Li (18275794), Jing Chen (4762)   +8 more
core   +1 more source

Hypomorphic human SEL1L and HRD1 variants uncouple multilayered ER-associated degradation machinery

The Journal of Clinical Investigation
The suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) complex of the endoplasmic reticulum–associated degradation (ERAD) machinery is a key cellular proteostasis pathway.
Katharine Umphred-Wilson, Stanley Adoro
doaj   +1 more source

Regulation of the Hrd1 Ubiquitin ligase during protein degradation at the endoplasmic reticulum

Misfolded or redundant proteins of the endoplasmic reticulum are degraded via ER associated degradation: They are recognized, undergo a retrotranslocation into the cytosol, become ubiquitinated, are extracted from the ER and are finally degraded via ...
Zaremba, Benjamin
core   +1 more source

Purkinje cell–specific deficiency in SEL1L-HRD1 endoplasmic reticulum–associated degradation causes progressive cerebellar ataxia in mice

JCI Insight
Recent studies have identified multiple genetic variants of SEL1L-HRD1 endoplasmic reticulum–associated degradation (ERAD) in humans with neurodevelopmental disorders and locomotor dysfunctions, including ataxia.
Mauricio Torres, Brent Pederson, Hui Wang, Liangguang Leo Lin, Huilun Helen Wang, Amara Bugarin-Lapuz, Zhen Zhao, Ling Qi   +7 more
doaj   +1 more source

HERPUD1 suppresses porcine epidemic diarrhea virus replication by recruiting HRD1 to degrade viral ORF3 protein. [PDF]

J Virol
Xu Y, Mou C, Xiang Y, Liu H, Bao W, Chen Z.   +5 more
europepmc   +1 more source

ERO1L induces macrophage infiltration to potentiate Kras^G12D and inflammation-induced pancreatic tumorigenesis via oxidative protein folding of CCL2. [PDF]

Cell Biosci
Zhang J, Hu C, Xu Y, Lu M, Ma Y, Yang T, Li J, Jiang SH, Jiang C, Chen P, Yao L, Hua R.   +11 more
europepmc   +1 more source

Comparative analysis of Cdc48-dependent proteolysis at the ER, mitochondria and chloroplasts. [PDF]

Nat Commun
Lau AS, Nellaepalli S, Jarvis RP.
europepmc   +1 more source

Ubiquitin-elongating enzyme Ufd2 confers resistance to hygromycin B in <i>Saccharomyces cerevisiae</i>. [PDF]

MicroPubl Biol
Paxton KM, Avaala JA, Creviston CS, Gumina J, True JD, Rubenstein EM.   +5 more
europepmc   +1 more source