Results 71 to 80 of about 3,624 (150)

The Flavivirus NS3 Protein: Its Multifaceted Roles and Therapeutic Potential

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
Abstract Mosquito‐borne flaviviruses are important human pathogenic viruses and can cause an array of symptoms ranging from asymptomatic to mild illness but can progress to severe disease conditions. Prominent members of the family Flaviviridae include Dengue virus, Zika virus, and West Nile virus, whose spread has increased globally due to the ...
Haejeong Lee, Hee Cho, Michaela U. Gack
wiley   +1 more source

Induction of HRD1 aggresome formation by oxidative stress.

, 2014
SH-SH5H cells treated with H2O2 (10 µM), rotenone (10 nM), and 4-HNE (15 µM) for 48 h and then subjected to immunofluorescence staining using HRD1 (red) and γ-tubulin (green) antibodies. Arrowheads, MTOC; arrows, HRD1 in aggresomes. Scale bars, 20 µm.
Kazuyuki Takata (558187), Masayuki Kaneko (558185), Yasuyuki Nomura (154321), Yoshihisa Kitamura (558186), Koichi Kawada (558188), Ryo Saito (519632), Yasunobu Okuma (154320)   +6 more
core   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, Volume 2, Issue 1, March 2026.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

ER-associated ubiquitin ligase HRD1 programs liver metabolism by targeting multiple metabolic enzymes

Nature Communications, 2018
HRD1 is an E3 ligase known to play a role in targeting degradation of misfolded proteins in the ER. Here the authors show that HRD1 interacts with metabolic enzymes and its liver specific deficiency results in lower body weight, blood glucose and plasma ...
Juncheng Wei, Yanzhi Yuan, Lu Chen, Yuanming Xu, Yuehui Zhang, Yajun Wang, Yanjie Yang, Clara Bien Peek, Lauren Diebold, Yi Yang, Beixue Gao, Chaozhi Jin, Johanna Melo-Cardenas, Navdeep S. Chandel, Donna D. Zhang, Hui Pan, Kezhong Zhang, Jian Wang, Fuchu He, Deyu Fang   +19 more
doaj   +1 more source

HRD1 prevents apoptosis in renal tubular epithelial cells by mediating eIF2α ubiquitylation and degradation

, 2017
Apoptosis of renal tubular epithelial cells is a key feature of the pathogenicity associated with tubulointerstitial fibrosis and other kidney diseases. One factor that regulates important cellular processes like apoptosis and cell proliferation is HRD1,
Dongming Su, Yizhi Cao, Yifei Sun, Min Li, Hui You, Xiubin Liang, Yujie Huang, Hui Sun, Yanjiao Li   +8 more
core   +1 more source

HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion

Cell Death and Disease
Intestinal ischemia/reperfusion (I/R) injury is a typical pathological course in the clinic with a high morbidity rate. Recent research has pointed out the critical role of ubiquitination during the occurrence and development of intestinal I/R by ...
Xuzi Zhao, Deshun Liu, Yan Zhao, Zhecheng Wang, Yue Wang, Zhao Chen, Shili Ning, Guangzhi Wang, Lu Meng, Jihong Yao, Xiaofeng Tian   +10 more
doaj   +1 more source

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase [PDF]

, 2012
Little is known about quality control of proteins that aberrantly or persistently engage the endoplasmic reticulum (ER)-localized translocon en route to membrane localization or the secretory pathway.
Robert Swanson, Wesley Greenblatt, Swanson, Robert, Rubenstein, Eric M., Mark Hochstrasser, Greenblatt, Wesley, Greenblatt, Wesley H., Stefan G. Kreft, Eric M. Rubenstein, Hochstrasser, Mark, Kreft, Stefan G.   +10 more
core   +1 more source

Integration of ER protein quality-control mechanisms defines β cell function and ER architecture

The Journal of Clinical Investigation, 2023
Three principal ER quality-control mechanisms, namely, the unfolded protein response, ER-associated degradation (ERAD), and ER-phagy are each important for the maintenance of ER homeostasis, yet how they are integrated to regulate ER homeostasis and ...
Neha Shrestha, Mauricio Torres, Jason Zhang, You Lu, Leena Haataja, Rachel B. Reinert, Jeffrey Knupp, Yu-Jie Chen, Allen H. Hunter, Gunes Parlakgul, Ana Paula Arruda, Billy Tsai, Peter Arvan, Ling Qi   +13 more
doaj   +1 more source

Inhibition of post-translational N-glycosylation by HRD1 that controls the fate of ABCG5/8 transporter [PDF]

, 2015
N-glycosylation of proteins in endoplasmic reticulum is critical for protein quality control. We showed here a post-translational N-glycosylation affected by the HRD1 E3 ubiquitin ligase.
Suico, Mary Ann, Kai, Hirofumi, Suzuki, Shingo, Kaneko, Masayuki, Cyr, Douglas M., Takada, Tappei, Sato, Takashi, Suzuki, Hiroshi, Shuto, Tsuyoshi   +8 more
core   +1 more source

Neuroprotection by Endoplasmic Reticulum Stress-Induced HRD1 and Chaperones: Possible Therapeutic Targets for Alzheimer’s and Parkinson’s Disease

Medical Sciences, 2016
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are neurodegenerative disorders with a severe medical and social impact. Further insights from clinical and scientific studies are essential to develop effective therapies.
Jun Nomura, Toru Hosoi, Masayuki Kaneko, Koichiro Ozawa, Akinori Nishi, Yasuyuki Nomura   +5 more
doaj   +1 more source