Results 61 to 70 of about 3,624 (150)

The ER-localised Hrd1 ubiquitinates and inactivates Usp15 to promote TLR4- induced inflammation during bacterial infection [PDF]

, 2019
The special organelle-located MAVS, STING and TLR3 are important for clearing viral infections. Although TLR4 triggers NF-κB activation to produce proinflammatory cytokines for bacteria clearance, effectors with special organelle localisation have not ...
Zhang, Yanbo, Xu, Xiaoyan, Han, Lei, Qiu, Ying, Chang, Haishuang, Zhong, Guisheng, Guo, Luqiang, Zhang, Fang, Xiao, Jun, Ma, Li, Wang, Hongyan, Lu, Yao, Zhong, Ruiyue, Chen, Peng, Li, Dangsheng, Hu, Ronggui, Zhang, Chi, He, Yongning, Zheng, Xin, Boyton, Rosemary, Huang, Ying, Wei, Bin   +21 more
core   +1 more source

Endoplasmic Reticulum Stress Induces HRD1 to Protect Alveolar Type II Epithelial Cells from Apoptosis Induced by Cigarette Smoke Extract

Cellular Physiology and Biochemistry, 2017
Background/Aims: Cigarette smoking is a major risk factor of chronic obstructive pulmonary disease. This study aimed to examine the effects of cigarette smoke extract (CSE) on alveolar type II epithelial cells (AECII) and investigate the underlying ...
Shuang-xiang Tan, Di-xuan Jiang, Rui-cheng Hu, Ai-guo Dai, Gui- xiang Gan, Dai-yan Fu, Chun-chu Kong, Yun-rong Chen, Li-Le Wang, Jie Li   +9 more
doaj   +1 more source

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

eFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu, Yubin Huang, Jianjun Deng, Zhijun Mao, Xue Bai, Longyang Ma, Jianhua Wang   +6 more
wiley   +1 more source

USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase

, 2016
In the endoplasmic reticulum (ER), misfolded and unfolded proteins are eliminated by a process called ER-associated protein degradation (ERAD) in order to maintain cell homeostasis.
Masako Kato, Nobuhiro Nakamura, Kumi Harada   +2 more
core   +1 more source

HIF-1α participates in the regulation of S100A16-HRD1-GSK3β/CK1α pathway in renal hypoxia injury

Cell Death and Disease
S100 calcium-binding protein 16 (S100A16) is implicated in both chronic kidney disease (CKD) and acute kidney injury (AKI). Previous research has shown that S100A16 contributes to AKI by facilitating the ubiquitylation and degradation of glycogen ...
Shuying Han, Runbing Jin, Lei Huo, Yunfei Teng, Lihua Zhao, Kaini Zhang, Rongfeng Li, Dongming Su, Xiubin Liang   +8 more
doaj   +1 more source

Characterization of the ubiquitylating components of the human malaria parasite's protein degradation pathway. [PDF]

PLoS ONE, 2012
Ubiquitin-dependent protein degradation within malarial parasites is a burgeoning field of interest due to several encouraging reports of proteasome inhibitors that were able to confer antimalarial activity. Despite the growing interest in the Plasmodium
Duk-Won D Chung, Nadia Ponts, Jacques Prudhomme, Elisandra M Rodrigues, Karine G Le Roch   +4 more
doaj   +1 more source

Roles of ER Membrane Protein Complex in Protein Biogenesis and Quality Control in the Lung and Beyond

Cell Proliferation, Volume 59, Issue 6, June 2026.
The endoplasmic reticulum membrane protein complex (EMC) is an evolutionarily conserved, multi‐subunit transmembrane protein complex crucial to membrane protein biogenesis and cellular protein quality control. This review systematically examines the structure, functions and disease‐associated regulatory mechanisms of EMC across multiple organ systems ...
Yan Qiao, Yuqing Sun, Yutao Huang, Qinghang Meng, Xinhua Lin, Wei Wei, Xiaofang Tang   +6 more
wiley   +1 more source

Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD

Nature Communications
The endoplasmic reticulum associated degradation (ERAD) pathway regulates protein quality control at the endoplasmic reticulum. ERAD of lumenal and membrane proteins requires a conserved E3 ubiquitin ligase, called Hrd1.
Basila Moochickal Assainar, Kaushik Ragunathan, Ryan D. Baldridge   +2 more
doaj   +1 more source

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, Volume 13, Issue 21, 13 April 2026.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

A Novel Tool to Study Hrd1 Complex Architecture [PDF]

Endgültig fehlgefaltete oder anderweitig beschädigte Proteine des Endoplasmatischen Retikulums (ER) werden durch das Proteasom in einem Prozess abgebaut, der als Endoplasmatischer Retikulum Assoziierter Abbau (ERAD) bezeichnet wird.
Abel, Tim Felix Michael Johannes
core   +1 more source