Results 41 to 50 of about 3,624 (150)

Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD) [PDF]

, 2017
The mammalian ubiquitin ligase Hrd1 is the central component of a complex facilitating degradation of misfolded proteins during the ubiquitin-proteasome dependent process of ER-associated degradation (ERAD). Hrd1 associates with cofactors to execute ERAD,
Avci, D, Christianson, JC, Aljona Gutschmidt, Jasmin Schulz, Norbert Volkmar, Volkmar, N, Dönem Avci, Thorsten Hoppe, Volkmar, Norbert, Hoppe, T, Yuki Hayashi, Queisser, Markus, Markus A. Queisser, Avci, Dönem, Gutschmidt, A, John C. Christianson, Queisser, MA, Hayashi, Y, Schulz, J, Emma J. Fenech, Dreher, LS, Lena-Sophie Dreher, Christianson, John, Fenech, Emma, Fenech, EJ, Schulz, Jasmin   +25 more
core   +1 more source

4-HNE modifications of HRD1 protein.

, 2014
A–B. SH-SY5Y cells were treated with or without 4-HNE for 24 h. The total cell lysates of NP-40-soluble (A) and -insoluble (B) fractions were analyzed by western blotting with the indicated antibodies. C.
Kazuyuki Takata (558187), Masayuki Kaneko (558185), Yasuyuki Nomura (154321), Yoshihisa Kitamura (558186), Koichi Kawada (558188), Ryo Saito (519632), Yasunobu Okuma (154320)   +6 more
core   +1 more source

Determination of the transmembrane topology of HRD1.

, 2012
A, B & C, The bioluminescence/fluorescence plots of the Gluc-GFP fusion forms of HRD1. HRD1 and its C-terminally truncated fragments were fused with the Gluc-GFP reporter. In the plots, the dashed lines indicate that the Gluc-GFP fusions are localized in
Hai-Yin Li (170623), Hong-Yu Hu (170637), Mei-Xia Che (170634), Xue-Ming Zheng (170629)   +3 more
core   +1 more source

TRIM31–LOX‐1 Axis: A Novel Therapeutic Frontier in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis, driven by a vicious cycle of lipid accumulation and chronic inflammation, underlies most cardiovascular diseases. Macrophages exacerbate this process by internalizing oxidized low‐density lipoprotein (oxLDL), forming foam cells, and releasing inflammatory mediators. A recent study published in Circulation identified the TRIM31–
Qian Zhang, Cheng Xue Qin
wiley   +1 more source

Improving protein secretion with autophagy‐inhibiting or proteasome‐activating small molecules

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND Therapeutic proteins are produced frequently by mammalian cells in large‐scale bioreactors. As a result, producer cells are exposed to a chemically (nutrients, gas exchange, target protein overexpression) and physically (shear due to mixing) stressful environment, which can lead to endoplasmic reticulum (ER) stress and loss of ...
R Chauncey Splichal, Christina Chan, S Patrick Walton   +2 more
wiley   +1 more source

PSEN1 Expression Identifies a Developmentally Distinct Favourable‐Prognosis State in SHH α Medulloblastoma

International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.
High PSEN1 expression identifies a favourable‐prognosis state in SHH α medulloblastoma and is associated with a reproducible transcriptional programme related to cellular homeostasis and development. Its broad expression during cerebellar development and across paediatric brain tumours suggests that its prognostic significance reflects the specific ...
Julia Vanini, Amanda Thomaz, Marina Müller Lupatini, André T. Brunetto, Caroline Brunetto de Farias, Mariane Jaeger, Rafael Roesler   +6 more
wiley   +1 more source

Hrd1 is required for CDT intoxication.

, 2014
(a) Co-immunoprecipitation of Derl2 and Hrd1. Derl2 was immunoprecipitated as in figure 2i and samples were analyzed for Hrd1 by western blot. (b) CRISPR mediated deletion of Hrd1 (ΔHrd1) results in decreased expression as judged by western blot of Hrd1 ...
Emily Jin-Kyung Kim (607026), Julia C. Kulik (607028), Robert Damoiseaux (326975), Steven R. Blanke (47138), Shandee D. Dixon (607024), Aria Eshraghi (607023), Kenneth A. Bradley (78125), Batcha Tamilselvam (607025), Amandeep Gargi (607027)   +8 more
core   +1 more source

Genetic Mapping for Winter‐Hardiness in a Miscanthus sacchariflorus × M. sinensis (Hardy × Non‐Hardy) F2 Population

GCB Bioenergy, Volume 18, Issue 10, October 2026.
Genetic mapping of a Miscanthus sacchariflorus × M. sinensis F2 population identified 37 QTLs associated with winter‐hardiness, including repeated regions across traits and years. Favorable alleles from the hardy M. sacchariflorus parent and candidate cold‐stress genes highlight targets for marker‐assisted breeding of winter‐hardy biomass cultivars ...
Xuying Zheng, Nick Labonte, Hongxu Dong, Shailendra Sharma, Katarzyna Glowacka, Lindsay V. Clark, John A. Juvik, Dessireé Zerpa‐Catanho, Erik J. Sacks   +8 more
wiley   +1 more source

The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes

Nature Communications, 2023
Endoplasmic reticulum (ER)-associated degradation (ERAD) and ER-phagy are two principal degradative mechanisms for ER proteins and aggregates, respectively; however, the crosstalk between these two pathways under physiological settings remains unexplored.
Shuangcheng Alivia Wu, Chenchen Shen, Xiaoqiong Wei, Xiawei Zhang, Siwen Wang, Xinxin Chen, Mauricio Torres, You Lu, Liangguang Leo Lin, Huilun Helen Wang, Allen H. Hunter, Deyu Fang, Shengyi Sun, Magdalena I. Ivanova, Yi Lin, Ling Qi   +15 more
doaj   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, Volume 13, Issue 54, 28 September 2026.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source