Results 31 to 40 of about 3,624 (150)

Downregulation of XBP1 protects kidney against ischemia-reperfusion injury via suppressing HRD1-mediated NRF2 ubiquitylation

Cell Death Discovery, 2021
Ischemia-reperfusion (IR) injury to the renal epithelia is associated with endoplasmic reticulum stress (ERS) and mitochondria dysfunction, which lead to oxidative stress-induced acute kidney injury (AKI).
Ji Zhang, Jiasi Zhang, Haiqiang Ni, Yanfeng Wang, Gaurav Katwal, Yuanyuan Zhao, Kailun Sun, Mengqin Wang, Qingwen Li, Gen Chen, Yun Miao, Nianqiao Gong   +11 more
doaj   +1 more source

Circadian Oscillation Pattern of Endoplasmic Reticulum Quality Control (ERQC) Components in Human Embryonic Kidney HEK293 Cells

Journal of Circadian Rhythms, 2023
The circadian clock regulates the “push-pull” of the molecular signaling mechanisms that arrange the rhythmic organization of the physiology to maintain cellular homeostasis. In mammals, molecular clock genes tightly arrange cellular rhythmicity.
Yalcin Erzurumlu, Deniz Catakli, Hatice Kubra Dogan   +2 more
doaj   +1 more source

HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation

iScience, 2020
Summary: ER-associated degradation (ERAD) targets misfolded ER proteins for degradation. Retrotranslocation, a key feature of ERAD, entails removal of ubiquitinated substrates into the cytosol for proteasomal destruction. Recently, it has been shown that
Sonya Neal, Della Syau, Anahita Nejatfard, Samantha Nadeau, Randolph Y. Hampton   +4 more
doaj   +1 more source

Proteomic characterization of endogenous substrates of mammalian ubiquitin ligase Hrd1

Cell & Bioscience, 2018
Background Endoplasmic reticulum (ER)-associated degradation (ERAD) regulates protein homeostasis in the secretory pathway by targeting misfolded or unassembled proteins for degradation by the proteasome. Hrd1 is a conserved multi-spanning membrane bound
Yilin Ye, Suk-Hwan Baek, Yihong Ye, Ting Zhang   +3 more
doaj   +1 more source

Downregulation of miR-221–3p promotes the ferroptosis in gastric cancer cells via upregulation of ATF3 to mediate the transcription inhibition of GPX4 and HRD1

Translational Oncology, 2023
Background: Gastric cancer (GC) is an aggressive gastrointestinal tumor. MiRNAs participate in the tumorigenesis of GC. Nevertheless, the function of miR-221–3p in GC remains largely unknown. Methods: RNA levels were assessed by RT-qPCR. Western blot was
Chang-Jiang Shao, Hai-Lang Zhou, Xu-Zhu Gao, Chun-Fang Xu   +3 more
doaj   +1 more source

HRD1 attenuates the high uptake of [18F]FDG in hepatocellular carcinoma PET imaging

, 2021
INTRODUCTION: Due to individual deviations in tumor tissue uptake, the role of [18F]fluorodeoxyglucose ([18F]FDG) positron emission tomography (PET) in hepatocellular carcinoma (HCC) diagnosis is limited.
Lin, Xia-Wen, Li, Min, Zheng, Qi-Huang, Zhou, Zheng-Yang, Shi, Ming, Shen, Jing-Tao, Li, Ai-Mei   +6 more
core   +1 more source

Hrd1 Partners In Endoplasmic Reticulum-Associated Degradation [PDF]

, 2015
Protein Quality Control (PQC) comprises cellular pathways that regulate the turnover of short-lived, misfolded proteins. A main component of PQC is Endoplasmic Reticulum (ER)-Associated Degradation (ERAD), which controls the degradation of proteins ...
Burr, Aaron Alexander
core   +1 more source

Funktionelle Charakterisierung des Hrd1-Proteins – einer Komponente der HRD-Ubiquitinligase [PDF]

, 2019
In Eukaryoten werden sekretorische Proteine an zytoplasmatischen Ribosomen synthetisiert und in das endoplasmatische Retikulum (ER) transportiert, wo sie ihre biologisch aktive Struktur erhalten.
Fichtner, Susanne
core   +1 more source

Hrd1 forms the retrotranslocation pore regulated by auto-ubiquitination and binding of misfolded proteins. [PDF]

, 2020
During endoplasmic-reticulum-associated protein degradation (ERAD), misfolded proteins are polyubiquitinated, extracted from the ER membrane and degraded by the proteasome1-4.
Schmidt, C., Meinecke, M., Alexander Stein, Vasic, Vedran, Stein, Alexander, Meinecke, Michael, Schmidt, Claudia C., Michael Meinecke, Riedel, D., Claudia C. Schmidt, Denkert, N., Dietmar Riedel, Riedel, Dietmar, Stein, A., Vedran Vasic, Vasic, V., Niels Denkert, Denkert, Niels   +17 more
core   +1 more source

Expression of the Ubiquitin Ligase HRD1 in Neural Stem/Progenitor Cells of the Adult Mouse Brain

Journal of Pharmacological Sciences, 2011
.: Neural stem/progenitor cells (NSCs) reside in the subventricular zone (SVZ) and subgranular zone of the hippocampal dentate gyrus in adult mammals. The ubiquitin ligase HRD1 is associated with degradation of amyloid precursor protein and believed to ...
Koichi Kawada, Masayuki Kaneko, Yasuyuki Nomura, Seisuke Mimori, Hiroshi Hamana, Kiyokazu Ogita, Toshihiko Murayama, Hiromichi Fujino, Yasunobu Okuma   +8 more
doaj   +1 more source