Results 11 to 20 of about 3,624 (150)

Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1 [PDF]

eLife, 2019
Misfolded proteins in the lumen of the endoplasmic reticulum (ER) are retrotranslocated into the cytosol and polyubiquitinated before being degraded by the proteasome.
Brian G Peterson, Morgan L Glaser, Tom A Rapoport, Ryan D Baldridge   +3 more
doaj   +3 more sources

Regulation of hepatic circadian metabolism by the E3 ubiquitin ligase HRD1-controlled CREBH/PPARα transcriptional program

Molecular Metabolism, 2021
Objective: The endoplasmic reticulum (ER)-resident E3 ligase HRD1 and its co-activator Sel1L are major components of ER-associated degradation (ERAD) machinery.
Hyunbae Kim, Juncheng Wei, Zhenfeng Song, Emilio Mottillo, Lobelia Samavati, Ren Zhang, Li Li, Xuequn Chen, Bhanu P. Jena, Jiandie D. Lin, Deyu Fang, Kezhong Zhang   +11 more
doaj   +3 more sources

Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease. [PDF]

PLoS ONE, 2014
The E3 ubiquitin ligase HRD1 is found in the endoplasmic reticulum membrane of brain neurons and is involved in endoplasmic reticulum-associated degradation. We previously demonstrated that suppression of HRD1 expression in neurons causes accumulation of
Ryo Saito, Masayuki Kaneko, Yoshihisa Kitamura, Kazuyuki Takata, Koichi Kawada, Yasunobu Okuma, Yasuyuki Nomura   +6 more
doaj   +2 more sources

Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders

The Journal of Clinical Investigation
Recent studies using cell type–specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum–associated (ER-associated ...
Huilun H. Wang, Liangguang L. Lin, Zexin J. Li, Xiaoqiong Wei, Omar Askander, Gerarda Cappuccio, Mais O. Hashem, Laurence Hubert, Arnold Munnich, Mashael Alqahtani, Qi Pang, Margit Burmeister, You Lu, Karine Poirier, Claude Besmond, Shengyi Sun, Nicola Brunetti-Pierri, Fowzan S. Alkuraya, Ling Qi   +18 more
doaj   +2 more sources

Structural insights into the human HRD1 ubiquitin ligase complex [PDF]

Nature Communications
In the endoplasmic reticulum (ER), defective proteins are cleaned via the ER-associated protein degradation (ERAD) pathway. The HRD1 ubiquitin ligase complex, with HRD1, SEL1L, XTP3B or OS9 and Derlin family proteins as the core components, plays ...
Liling Guo, Guoyun Liu, Jingjing He, Xiaoxiao Jia, Yonglin He, Zhenhua Wang, Hongwu Qian   +6 more
doaj   +2 more sources

ERAD Component MoHrd3 Facilitates Pathogenicity and Establishes a Direct Regulation on Autophagy in Magnaporthe Oryzae. [PDF]

Adv Sci (Weinh)
MoHrd3 plays a crucial role in regulating the pathogenicity of Magnaporthe oryzae. As an ER‐associated degradation component, MoHrd3 involves in ER stress‐triggered autophagy. It facilitates the fusion between the autophagosome and the vacuole via enhancing the interaction between MoAtg8 and MoYpt7.
Xia H, Zheng Y, Yang N, Chen J, Wu X, Zheng X, Cui D, Wang R, Lu X, Wang D, Peng YL, Chen Q.   +11 more
europepmc   +2 more sources

GLI2-HRD1 axis facilitates 5-FU resistance in gastric cancer cells by regulating ubiquitination degradation of UCK2 [PDF]

Translational Oncology
5-Fluorouracil (5-FU) is a primary chemotherapeutic agent for treating gastric cancer (GC), yet resistance to 5-FU frequently limits its effectiveness and contributes to poor patient outcomes.
Chaorong Xue, Xuanzi Zhang, Wanling Yu, Hanbin Lin, Junrong Zhang, Jiawen Liu, Zongqi Weng, Manduo Ouyang, Xinjian Lin   +8 more
doaj   +2 more sources

The ER membrane-anchored ubiquitin ligase Hrd1 is a positive regulator of T-cell immunity

Nature Communications, 2016
Hrd1 is an E3 ubiquitin ligase involved in ER-associated degradation and MHC I turnover. Here the authors use T-cell-specific ko mice and a mouse model of multiple sclerosis to show that Hrd1 also drives pro-inflammatory T helper cell responses and ...
Yuanming Xu, Fang Zhao, Quan Qiu, Kun Chen, Juncheng Wei, Qingfei Kong, Beixue Gao, Johanna Melo-Cardenas, Bin Zhang, Jinping Zhang, Jianxun Song, Donna D. Zhang, Jianing Zhang, Yunping Fan, Huabin Li, Deyu Fang   +15 more
doaj   +2 more sources

Natural genetic variation of a single amino acid in beet necrotic yellow vein virus P31 protein modulates evasion of plant ubiquitination-mediated antiviral immunity. [PDF]

PLoS Pathogens
Plant virus evolution frequently leads to the emergence of highly virulent strains, posing persistent threats to global crop production. However, the mechanisms by which viral evolution enables evasion of plant defense responses remain poorly understood.
Zhi-Hong Guo, Xin-Yu Qin, Meng-Ke Zhou, Xiu-Qi Zhang, Zhi-Yao Li, Chuan Zheng, Zong-Ying Zhang, Qian Chen, Xian-Bing Wang, Cheng-Gui Han, Ying Wang   +10 more
doaj   +2 more sources

HRD1 negatively regulates autolysosome formation by inhibiting liquid-liquid phase separation of SNAP29

Cell Reports
Summary: Autophagy is a highly conserved cellular process in which cytoplasmic contents are sequestrated by autophagosomes and delivered to lysosomes for degradation.
Wenyan Qu, Di Chen, Hongyu Zhao, Qiang Sheng, Juan Wang, Yujun Shen, Yuxian Shen   +6 more
doaj   +2 more sources