Results 21 to 30 of about 3,624 (150)

Neuronal SEL1L-HRD1 ER-associated degradation is essential for motor function and survival in mice [PDF]

The Journal of Clinical Investigation
Hypomorphic variants in the SEL1L-HRD1 ER-associated degradation (ERAD) complex have been linked to severe neurological syndromes in children, including neurodevelopmental delay, intellectual disability, motor dysfunction, and early death.
Mauricio Torres, You Lu, Brent Pederson, Hui Wang, Anna Gretzinger, Liangguang L. Lin, Jiwon Hwang, Xinxin Chen, Alan C. Rupp, Abigail J. Tomlinson, Andrew J. Scott, Zhen Zhao, Daniel R. Wahl, Martin G. Myers Jr., Costas A. Lyssiotis, Ling Qi   +15 more
doaj   +2 more sources

Sel1L‐Hrd1‐Mediated OS9 Degradation During Endoplasmic Reticulum Stress [PDF]

, 2014
Misfolded or unfolded proteins generated by inefficient protein folding or ER stress is translocated from the ER to cytosol for proteasome degradation, a process termed endoplasmic reticulum associated degradation (ERAD).
Shu, Xin
core   +6 more sources

Deep mutational scanning highlights a role for cytosolic regions in Hrd1 function

Cell Reports, 2023
Summary: Misfolded endoplasmic reticulum (ER) proteins are degraded through a process called ER-associated degradation (ERAD). Soluble, lumenal ERAD targets are recognized, retrotranslocated across the ER membrane, ubiquitinated, extracted from the ...
Brian G. Peterson, Jiwon Hwang, Jennifer E. Russ, Jeremy W. Schroeder, P. Lydia Freddolino, Ryan D. Baldridge   +5 more
doaj   +1 more source

CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer

Molecular Cancer, 2021
Background E3 ubiquitin ligase HRD1 (HMG-CoA reductase degradation protein 1, alias synoviolin with SYVN1 as the official gene symbol) was found downregulated and acting as a tumor suppressor in breast cancer, while the exact expression profile of HRD1 ...
Ya Fan, Jia Wang, Wen Jin, Yifei Sun, Yuemei Xu, Yipin Wang, Xiubin Liang, Dongming Su   +7 more
doaj   +1 more source

Dissecting the Mechanics of Hrd1 Mediated ERAD

, 2023
Approximately one-third of proteins fold within the endoplasmic reticulum (ER), and the ER employs several protein quality control systems to either refold or degrade misfolded proteins.
Peterson, Brian
core   +1 more source

Anti-Warburg effect by targeting HRD1-PFKP pathway may inhibit breast cancer progression

Cell Communication and Signaling, 2021
Background Our previous studies have shown that the E3 ubiquitin ligase of HMG-CoA reductase degradation 1 (HRD1) functions as a tumor suppressor, as overexpression of HRD1 suppressed breast cancer proliferation and invasion.
Ya Fan, Jia Wang, Yuemei Xu, Yipin Wang, Tao Song, Xiubin Liang, Feng Jin, Dongming Su   +7 more
doaj   +1 more source

Host E3 ligase Hrd1 ubiquitinates and degrades H protein of canine distemper virus to inhibit viral replication

Veterinary Research, 2023
Canine distemper (CD) is a highly contagious and an acutely febrile disease caused by canine distemper virus (CDV), which greatly threatens the dog and fur industry in many countries.
Wenjie Wang, Zhenwei Bi, Suquan Song
doaj   +1 more source

SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer

iScience, 2022
Summary: Endoplasmic reticulum (ER) homeostasis has been implicated in the pathogenesis of various forms of cancer; however, our understanding of the role of ER quality control mechanisms in tumorigenesis remains incomplete.
Asmita Bhattacharya, Juncheng Wei, Wenxin Song, Beixue Gao, Chunyan Tian, Shuangcheng Alivia Wu, Jian Wang, Ligong Chen, Deyu Fang, Ling Qi   +9 more
doaj   +1 more source

Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Todi, S. V., Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A.   +14 more
core   +2 more sources

Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease: Possible Involvement of HRD1, a Novel Molecule Related to Endoplasmic Reticulum Stress, in Alzheimer’s Disease

Journal of Pharmacological Sciences, 2012
Endoplasmic reticulum (ER)-associated degradation (ERAD) is a protective mechanism against ER stress in which unfolded proteins accumulated in the ER are selectively transported to the cytosol for degradation by the ubiquitin–proteasome system. We cloned
Masayuki Kaneko, Yasunobu Okuma, Yasuyuki Nomura   +2 more
doaj   +1 more source