Results 171 to 180 of about 13,686 (217)

Deciphering the role of <i>Th</i>HSF1 in the differential expression regulation of laccase isozymes in the white-rot fungus <i>Trametes hirsuta</i>. [PDF]

Microbiol Spectr
Wu K, Zhu R, Zhao S, Wang C, Zhang X, Liu S, Fang Z, Xiao Y, Liu J.   +8 more
europepmc   +1 more source

Nuclear stress bodies: a potential mechanism to shut off lethal inflammatory cytokines. [PDF]

Signal Transduct Target Ther
Kim CH.
europepmc   +1 more source

Logic-Gated HSV-TK/GCV Suicide Gene Circuit for Triple-Negative Breast Cancer. [PDF]

Adv Sci (Weinh)
Tang S, Fang Y, Jin L, Liu D, Liu Y, Zheng R, Yong L, Wu X, Qiao L, Wang M, Cai F.   +10 more
europepmc   +1 more source

Quercetagetin Ameliorates Heat Stress-Induced Intestinal Damage via Oxidative Stress, Inflammation and Gut Microbiota in Mice. [PDF]

Microorganisms
Huang X, Wang M, Qing Z, Zeng J.
europepmc   +1 more source

Multifaceted roles of mammalian heat shock factor 1 in the central nervous system. [PDF]

Cell Stress Chaperones
Rozema NB, Gomez-Pastor R.
europepmc   +1 more source

Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response. [PDF]

Nat Commun
Omkar S, Kline JT, Grissom JH, Sun D, Chi RJ, Bard JAM, Fornelli L, Truman AW.   +7 more
europepmc   +1 more source

HSF1: Guardian of Proteostasis in Cancer [PDF]

Trends in Cell Biology, 2016
Proteomic instability is causally related to human diseases. In guarding proteome stability, the heat shock factor 1 (HSF1)-mediated proteotoxic stress response plays a pivotal role. Contrasting with its beneficial role of enhancing cell survival, recent findings have revealed a compelling pro-oncogenic role for HSF1. However, the mechanisms underlying
Chengkai Dai
exaly   +6 more sources

HSF1 as a Cancer Biomarker and Therapeutic Target [PDF]

Current Cancer Drug Targets, 2019
Heat shock factor 1 (HSF1) was discovered in 1984 as the master regulator of the heat shock response. In this classical role, HSF1 is activated following cellular stresses such as heat shock that ultimately lead to HSF1-mediated expression of heat shock proteins to protect the proteome and survive these acute stresses. However, it is now becoming clear
Yesim Gokmen-Polar, Carpenter R L
exaly   +5 more sources

AKT1 mediates multiple phosphorylation events that functionally promote HSF1 activation [PDF]

FEBS Journal, 2022
The heat stress response activates the transcription factor heat shock factor 1 (HSF1), which subsequently upregulates heat shock proteins to maintain the integrity of the proteome.
Carpenter R L
exaly   +2 more sources

Multifaceted roles of HSF1 in cancer

Tumor Biology, 2015
Heat shock transcription factor 1 (HSF1) is the master regulator of the heat shock response. Accumulating evidence shows that HSF1 is overexpressed in a variety of human cancers, is associated with cancer aggressiveness, and could serve as an independent diagnostic or prognostic biomarker. In this review, we will provide an overview of the multifaceted
Yuhua Zhao, Zhao Yuhua
exaly   +3 more sources