Results 101 to 110 of about 39,355 (215)

New markers of bleomycin resistance [PDF]

, 2019
Resistance to chemotherapy is one of the main problems of this type of therapy. Studies carried out determine the usefulness of predictive biomarkers to improve this treatment.
Burgos-Molina, Antonio Manuel, Gil-Carmona, Luisa, Ruiz-Gomez, Miguel Jose   +2 more
core  

Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells. [PDF]

, 2008
Hsp60, a mitochondrial chaperonin highly conserved during evolution, has been found elevated in the cytosol of cancer cells, both in vivo and in vitro, but its role in determining apoptosis during oxidative stress (OS) has not yet been fully elucidated ...
Ardizzone, NM, BELLAFIORE, Marianna, BUCCHIERI, Fabio, CAMPANELLA, Claudia, CAPPELLO, Francesco, Conway de Macario, E, Czarnecka, AM, DAVID, Sabrina, DI FELICE, Valentina, FARINA, Felicia, Macario, AJ, Marasà, M, MARINO GAMMAZZA, Antonella, Montalbano, A, PERI, Giovanni, RAPPA, Francesca, Ribbene, A, ZUMMO, Giovanni   +17 more
core   +2 more sources

Intra- and interspecies interactions between prion proteins and effects of mutations and polymorphisms [PDF]

, 2003
Recently, crystallization of the prion protein in a dimeric form was reported. Here we show that native soluble homogenous FLAG-tagged prion proteins from hamster, man and cattle expressed in the baculovirus system are predominantly dimeric.
Bradley R., Campbell T.A., Clark W.W., Cutlip R.C., Edenhofer F., Goldfarb L.G., Krasemann S., Leucht C., Lopez L., Majtenyi C., Scott M.R., Weiss S.   +11 more
core   +1 more source

Hsp60 response in experimental and human temporal lobe epilepsy [PDF]

, 2015
The mitochondrial chaperonin Hsp60 is a ubiquitous molecule with multiple roles, constitutively expressed and inducible by oxidative stress. In the brain, Hsp60 is widely distributed and has been implicated in neurological disorders, including epilepsy ...
Bello, Margherita Lo, Benigno, Arcangelo, Bucchieri, Fabio, Cappello, Francesco, Colangeli, Roberto, Conway de Macario, Everly, D'Aniello, Alfredo, Di Giovanni, Giuseppe, Gennaro, Giancarlo di, Macario, Alberto J. L., Marino Gammazza, Antonella, Muscat, Richard, Orban, Gergely, Pierucci, Massimo, Pomara, Cristoforo, Valentino, Mario, Zummo, Giovanni   +16 more
core   +1 more source

Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?

Journal of Diabetes Research, 2016
The focus of this review is to summarise the known relationships between the expression of heat shock protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type 2 diabetes mellitus.
Joshua Juwono, Ryan D. Martinus
doaj   +1 more source

Developmental and hyperthermia-induced expression of the heat shock proteins HSP60 and HSP70 in tissues of the housefly Musca domestica: an in vitro study

Genetics and Molecular Biology, 2007
The expression pattern of two major chaperones, the heat shock proteins (HSPs) HSP60 and HSP70 was studied in vitro in tissues of the housefly Musca domestica during larval and adult stages of development to identify their immunological relatives and ...
Sunita Sharma, Manoj Singh Rohilla, Pramod Kumar Tiwari   +2 more
doaj   +1 more source

Clinicopathologic significance of heat shock protein 60 as a survival predictor in breast carcinoma

Frontiers in Oncology
BackgroundWhile Heat Shock Protein 60 (HSP60) has been linked to human tumor, its clinic significance specifically in breast carcinoma is unclear. This investigation aims to retrospectively evaluate how HSP60 protein levels relate to survival outcomes ...
Qing Wang, Shengzhou Chen, Zhihong Wu, Jungang Ni   +3 more
doaj   +1 more source

Expression of the 60 and 70 kDa Family of Heat Shock Proteins in Trachea Epithelium Cells of Poults Experiencing Bordetellosis

Poultry
Heat shock protein (HSP) gene families are known to be expressed preferentially over normal cellular proteins when poultry cells are exposed to environmental stressors.
Frank W. Edens
doaj   +1 more source

Identification and Clinical Validation of High HSP60 Expression Predicts Poor Prognosis in Patients with Ovarian Cancer

International Journal of General Medicine
Min Zheng,1,* Shaoxing Li,1,* Jie Deng,1 Chaolin Huang,1 Hua Zhang2 1Department of Gynecology and Obstetrics, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, People’s Republic of China; 2Department ...
Zheng M, Li S, Deng J, Huang C, Zhang H
doaj  

HSP60 Reduction Causes an Abnormal Genotype and Sex Distribution and Impairs Mitochondrial Activity in Mouse Spermatozoa

Reproductive Medicine
Background/Objective: Fertility relies on efficient energy metabolism in gametes, which is largely determined by mitochondrial activity. The mitochondrial chaperone complex HSP60/HSP10 folds the majority of mitochondrial matrix proteins and thus enables ...
Robert Hauffe, Michaela Rath, Simran Chopra, Karin Müller, André Kleinridders   +4 more
doaj   +1 more source