Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]
, 2009 The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele +8 more
core +1 more source
Relationships Among Beef Cow Productivity Traits and Single Nucleotide Polymorphisms in the Bovine Heat Shock Protein 70 Gene [PDF]
, 2018 When eukaryotes are exposed to stressors such as heat, toxins, and low oxygen levels, heat shock proteins (HSPs) are synthesized to maintain normal cellular function within the body.
Finney, Ashley
core +2 more sources
Heat shock proteins in health and disease: therapeutic targets or therapeutic agents? [PDF]
, 2001 For many years, heat shock or stress proteins have been regarded as intracellular molecules that have a range of housekeeping and cytoprotective functions, only being released into the extracellular environment in pathological situations such as necrotic
Pockley, A.G.
core +1 more source
Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells. [PDF]
, 2008 Hsp60, a mitochondrial chaperonin highly conserved during evolution, has been found elevated in the cytosol of cancer cells, both in vivo and in vitro, but its role in determining apoptosis during oxidative stress (OS) has not yet been fully elucidated ...
Ardizzone, NM +17 more
core +2 more sources
Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]
, 2013 Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba +10 more
core +3 more sources
Does Hsp60 Provide a Link between Mitochondrial Stress and Inflammation in Diabetes Mellitus?
Journal of Diabetes Research, 2016 The focus of this review is to summarise the known relationships between the expression of heat shock protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type 2 diabetes mellitus.
Joshua Juwono, Ryan D. Martinus
doaj +1 more source
Hyperglycaemia and oxidative stress upregulate HSP60 & HSP70 expression in HeLa cells [PDF]
, 2013 Heat Shock Proteins 60 & 70 (HSP60 & HSP70) are intracellular protein that has been shown to be present at elevated levels in systemic circulation in Type 2 Diabetes mellitus (T2DM) patients.
Hall, Luke, Martinus, Ryan Dennis
core +2 more sources
Genetics and Molecular Biology, 2007 The expression pattern of two major chaperones, the heat shock proteins (HSPs) HSP60 and HSP70 was studied in vitro in tissues of the housefly Musca domestica during larval and adult stages of development to identify their immunological relatives and ...
Sunita Sharma +2 more
doaj +1 more source
Clinicopathologic significance of heat shock protein 60 as a survival predictor in breast carcinoma
Frontiers in OncologyBackgroundWhile Heat Shock Protein 60 (HSP60) has been linked to human tumor, its clinic significance specifically in breast carcinoma is unclear. This investigation aims to retrospectively evaluate how HSP60 protein levels relate to survival outcomes ...
Qing Wang +3 more
doaj +1 more source
Reproductive MedicineBackground/Objective: Fertility relies on efficient energy metabolism in gametes, which is largely determined by mitochondrial activity. The mitochondrial chaperone complex HSP60/HSP10 folds the majority of mitochondrial matrix proteins and thus enables ...
Robert Hauffe +4 more
doaj +1 more source