Results 91 to 100 of about 158,688 (339)

Multiphysics‐Driven Assembly of Biomimetic Vesicles

Advanced Materials, EarlyView.
Artificial extracellular vesicles, derived from cell membranes, are manufactured using a multiphysics‐integrated microfluidic platform that combines nanoknife membrane rupture, herringbone chaotic mixing, and acoustothermal modulation. This standardizable workflow enables the predictable control of vesicle formation and therapeutic loading, while ...
Timofei Solodko, Ian Gimino, Aastha Chandiwala, Bayan Alkotoub, Ali Bashiri Dezfouli, Heiko Reith, Asjad Bakhtiar, Rojda Hicsanmaz, Johann Brenner, Christoph J. O. Kaiser, Elena Belli, Shilpi Pandey, Samuel D. Rabkin, Kornelius Nielsch, Gabriele Multhoff, Oliver Hayden, Morteza Hasanzadeh Kafshgari   +16 more
wiley   +1 more source

Transcriptome analysis revealed the molecular mechanism by which Chrysanthemum naktongense roots respond to low-concentration lanthanum treatment

Ornamental Plant Research
Chrysanthemum naktongense (C. naktongense) is widely distributed in northern China, and has high biomass and strong resistance. Lanthanum is a nonessential heavy metal element in plants, and it affects C.
Yaohui Gao, Ruiqing Zhang, Ning Xu, Ying Song, Shiao Chen, Miao He   +5 more
doaj   +1 more source

Proteostasis by STUB1/HSP70 complex controls sensitivity to androgen receptor targeted therapy in advanced prostate cancer. [PDF]

, 2018
Protein homeostasis (proteostasis) is a potential mechanism that contributes to cancer cell survival and drug resistance. Constitutively active androgen receptor (AR) variants confer anti-androgen resistance in advanced prostate cancer. However, the role
Armstrong, Cameron M, Chen, Hong-Wu, Dall'Era, Marc, Evans, Christopher P, Gao, Allen C, Liu, Chengfei, Liu, Liangren, Lombard, Alan P, Lou, Wei, Noel, Onika DV, Tepper, Clifford G, Yang, Joy C, Zhao, Ruining   +12 more
core   +2 more sources

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Cold Exposure-Induced Up-Regulation of Hsp70 Positively Regulates PEDV mRNA Synthesis and Protein Expression In Vitro

Pathogens, 2020
Porcine epidemic diarrhea (PED) is a highly contagious, intestinal infectious disease caused by porcine epidemic diarrhea virus (PEDV). PEDV as an emerging and re-emerging epizootic virus of swine causes substantial economic losses to the pig industry in
Fanzhi Kong, Yaru Xu, Wei Ran, Baishuang Yin, Li Feng, Dongbo Sun   +5 more
doaj   +1 more source

Responses of heat shock protein 70 and caspase-3/7 to dietary selenomethionine in juvenile white sturgeon. [PDF]

, 2016
An 8-week feeding trial was conducted to investigate the responses of juvenile white sturgeon (Acipenser transmontanus) to elevated dietary selenium (Se) based on the determination of the RNA/DNA ratio in muscle, heat shock protein 70 (Hsp70), and ...
Deng, Dong-Fang, Hung, Silas SO, Lee, Seunghyung, Wang, Weifang   +3 more
core   +1 more source

CHB‐Induced Immune Zonation Chaos Elicited LXRα‐mediated Lipid Metabolism Disorders in Kupffer Cells to Induce Cancer Stem Cell Formation

Advanced Science, EarlyView.
By profiling the spatiotemporal hepatic landscape of CHB mouse models, the originally peri‐portal localized KCs migrated to the peri‐central in a CXCL9‐CXCR3‐dependent manner, facilitating their interaction with HBV+ hepatocytes. The interaction promoted LMD in KCs through ASGR1‐induced LXRα degradation, which, in turn, induced CSC formation via Stat3 ...
Jingqi Shi, Qingyu Li, Jian Li, Jian Bai, Ji Xi, Qi He, Jianglin Zhou, Xuejun Wang, Xiang Song, Xiaoju Li, Xiangpei Yue, Xiaochang Zhang, Zhen Sun, Jiangbo Li, Wen Yang, Yuke Cui, Wenjie Shu, Liang Guo, Shengqi Wang   +18 more
wiley   +1 more source

Pleiotropic and Novel Phenotypes in The \u3cem\u3eDrosophila\u3c/em\u3e Gut Caused by Mutation of \u3cem\u3eDrop-Dead\u3c/em\u3e [PDF]

, 2018
Normal gut function is vital for animal survival, and deviations from such function can contribute to malnutrition, inflammation, increased susceptibility to pathogens, diabetes, neurodegenerative diseases, and cancer.
Benske, Anika, Billen, Johan, Blumenthal, Edward M., Conway, Sean, Kentala, Kaitlin, Sansone, Christine Lynn, Vanden Broeck, Jozef   +6 more
core   +1 more source

Skeletal Muscle HSF1 Alleviates Age‐Associated Sarcopenia and Mitochondrial Function Decline via SIRT3‐PGC1α Axis

Advanced Science, EarlyView.
Aged HSF1 muscle‐specific knockout mice show deteriorated muscle atrophy and metabolic dysfunction, while active HSF1 overexpression improves muscle function via activating SIRT3 to deacetylate both PGC1α1 and PGC1α4, which boosts mitochondrial function and muscle hypertrophy in a fiber‐type specific manner, and induces FNDC5/Irisin for tissue ...
Jun Zhang, Min Hu, Xia Wu, Mingwei Guo, Ying Ma, Jin Qiu, Siqi Wang, Yuxiang Cao, Yinzhao Zhong, Fangfang Chen, Yiwen Wang, Wei Wei, Yan Lu, Yong Zhang, Junjie Xiao, Zhenji Gan, Cheng Hu, Xinran Ma, Lingyan Xu   +18 more
wiley   +1 more source

Primer informe de Leishmania naiffi en Zamora Chinchipe (Ecuador) utilizando el gen que codifica la proteína HSP70

Cedamaz, 2021
En Ecuador se encuentran informadas algunas de las especies de Leishmania pertenecientes al subgénero Viannia (V), causante de enfermedades como leishmaniasis cutánea, cutánea difusa no curativa y mucocutánea. El objetivo de este trabajo fue diagnosticar
Luis Alberto Morocho-Yaguana, Gina Stefany Jaramillo-Balcázar, Franklin Román-Cárdenas, Loidy Zamora-Gutiérrez   +3 more
doaj