Results 71 to 80 of about 158,688 (339)

Swapping Nucleotides, Tuning Hsp70 [PDF]

Cell, 2008
Molecular chaperones such as heat shock protein 70 (Hsp70) are crucial for protein folding. Crystal structures of Hsp70 in a complex with the nucleotide exchange factor (NEF) Hsp110 reported in this issue of Cell (Polier et al., 2008) and in Molecular Cell (Schuermann et al., 2008) provide new insights into how NEF action specifies Hsp70 cellular ...
openaire   +2 more sources

Enhancing Magnetic Hyperthermia at the Cell Membrane by Anchoring 92R‐Functionalized Magnetic Nanoparticles to Low‐Endocytic CCR9 Surface Receptors

Advanced Healthcare Materials, EarlyView.
We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente, Isabel Corraliza‐Gorjón, Thomas S. van Zanten, María del Puerto Morales, Leonor Kremer, Domingo F. Barber   +5 more
wiley   +1 more source

secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids

Fly, 2017
Self-association of amyloidogenic proteins is the main pathological trigger in a wide variety of neurodegenerative disorders. These aggregates are deposited inside or outside the cell due to hereditary mutations, environmental exposures or even normal ...
Lorena De Mena, Deepak Chhangani, Pedro Fernandez-Funez, Diego E. Rincon-Limas   +3 more
doaj   +1 more source

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]

, 2008
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
Argent, Argent, Arndt, Brodsky, Brodsky, C. Rogon, Chaddock, Chen, Hudson, Hundley, H  hfeld, J. Hohfeld, J. M. Lord, J. P. Cook, L. M. Roberts, Lawson, Luders, Meacham, Meusser, Nakatsukasa, Nakatsukasa, P. J. Hart, P. Pietroni, R. A. Spooner, Rapak, Roe, Savino, Spooner, Urushitani, van Deurs, Wales, Wesche, Younger   +32 more
core   +2 more sources

Isolation Defines Identity: Functional Consequences of Extracellular Vesicle Purification Strategies

Advanced Healthcare Materials, EarlyView.
Four extracellular vesicle purification strategies are compared using ovarian‐cancer ascites and ES‐2 cell supernatants. A novel workflow links purification to function by combining particle‐normalized proteomics with matched cell‐free and cell‐based assays.
Christian Preußer, Dolores J. Salander, Witold Szymanski, Johannes Graumann, Yukai Wang, Kai Zhao, Jörg W. Bartsch, María Gómez‐Serrano, Daniel Bachurski, Silke Reinartz, Elke von Pogge von Strandmann   +10 more
wiley   +1 more source

Interaction of human heat shock protein 70 with tumor-associated peptides [PDF]

, 2009
Molecular chaperones of the heat shock protein 70 (Hsp70) family play a crucial role in the presentation of exogenous antigenic peptides by antigen-presenting cells (APCs).
Bendz, Bendz, Bernhardt, Bernhardt, Calderwood, Calderwood, Carilli, Carilli, Castellino, Castellino, Davis, Davis, Elguindi, Elguindi, Farr, Farr, Fernández, Fernández, Flechtner, Flechtner, Flynn, Flynn, Fourie, Fourie, Germeroth, Germeroth, Gragerov, Gragerov, Hartl, Hartl, Ishii, Ishii, Kawakami, Kawakami, Kelley, Kelley, Knarr, Knarr, Laemmli, Laemmli, Landry, Landry, Mayer, Mayer, Mayer, Mayer, Mayer, Mayer, McCarty, McCarty, Milani, Milani, Moroi, Moroi, Multhoff, Multhoff, Noessner, Noessner, Norby, Norby, Stevens, Stevens, Suto, Suto, Takeda, Takeda, Udono, Udono, Udono, Udono, Ueda, Ueda, Visseren, Visseren, Wegele, Wegele, Wölfel, Wölfel, Zheng, Zheng, Zhu, Zhu   +81 more
core   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

A Comparative Analysis of hsp70 mRNA and HSP70 Protein Expression in Two Distant Populations of the Baikal Amphipod Eulimnogammarus verrucosus (Gerstf., 1858) [PDF]

Journal of Stress Physiology & Biochemistry, 2013
Basal levels of hsp70 (mRNA) and HSP70 (protein) were measured in representatives from two distant populations of the amphipod Eulimnogammarus verrucosus (Gerstf.) endemic to Lake Baikal using quantitative PCR (qPCR) and Western blotting upon lab ...
Madyarova E.V., Lubyaga J.А., Gurkov А.N., Vereshchagina К.P., Kondrat’eva Е.М., Shchapova Е.P., Timofeyev М.А., Luckenbach T., Bedulina D.S.   +8 more
doaj  

Effects of hepatitis C virus NS3 protein on expression of heat shock protein 70 and Glypican3 as the markers of hepatocellular carcinoma

مجله دانشگاه علوم پزشکی بیرجند, 2021
Background and Aims: Hepatitis C virus (HCV) infection is an important risk factor for the development of liver cancer. The HCV NS3 protein plays a key role in the virus life cycle and can affect normal cellular activities, such as cell proliferation ...
Sepideh Saeb, Farzaneh Sabahi, Zohreh Mazaheri, Mehrdad Ravanshad   +3 more
doaj  

The hsp70 new functions as a regulator of reproduction both female and male in Ophraella communa

Frontiers in Molecular Biosciences, 2022
Heat shock proteins (Hsps) function as molecular chaperones that enable organisms to withstand stress and maintain normal life activities. In this study, we identified heat shock protein 70 (encoded by hsp70), which exhibits a higher expression in the ...
Yan Zhang, Weihua Ma, Chao Ma, Qinglu Zhang, Zhenya Tian, Zhenya Tian, Zhenqi Tian, Hongsong Chen, Hongsong Chen, Jianying Guo, Fanghao Wan, Zhongshi Zhou, Zhongshi Zhou   +12 more
doaj   +1 more source