Results 1 to 10 of about 138,190 (352)
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 [PDF]
Experimental and Molecular Medicine, 2020 Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment.
Chae, Young Chan +10 more
core +2 more sources
Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics [PDF]
Open Biology, 2012 Heat shock protein 90 (Hsp90) is a promising cancer drug target as a molecular chaperone critical for stabilization and activation of several of the oncoproteins that drive cancer progression.
Peter W. Piper, Stefan H. Millson
doaj +4 more sources
Scientific Reports, 2021 Our previous study demonstrated increased expression of Heat shock protein (Hsp) 90 in the skin of patients with systemic sclerosis (SSc). We aimed to evaluate plasma Hsp90 in SSc and characterize its association with SSc-related features. Ninety-two SSc
H. Štorkánová +11 more
semanticscholar +1 more source
International Journal on Biological Sciences, 2023 Timosaponin AIII (Tim-AIII), a steroid saponin, exhibits strong anticancer activity in a variety of cancers, especially breast cancer and liver cancer. However, the underlying mechanism of the effects of Tim-AIII-mediated anti-lung cancer effects remain ...
Cong Zhou +15 more
semanticscholar +1 more source
HSP90 inhibitors and cancer: Prospects for use in targeted therapies (Review)
Oncology Report, 2022 Heat shock protein 90 (HSP90) is a vital chaperone protein, regulating signaling pathways and correcting misfolded proteins in cancer cells by interacting with oncogenic client proteins and co-chaperones.
Zi-Nan Li, Ying Luo
semanticscholar +1 more source
Co-crystalization and in vitro biological characterization of 5-Aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors [PDF]
, 2012 A potential therapeutic strategy for targeting cancer that has gained much interest is the inhibition of the ATP binding and ATPase activity of the molecular chaperone Hsp90.
Chrisostomos Prodromou +7 more
core +9 more sources
Cancer Biology & Therapy, 2022 Mitochondria are key tumor drivers, but their suitability as a therapeutic target is unknown. Here, we report on the preclinical characterization of Gamitrinib (GA mitochondrial matrix inhibitor), a first-in-class anticancer agent that couples the Heat ...
Umar Hayat +3 more
doaj +1 more source
International Journal of Molecular Sciences, 2021 HSP90 is a vital chaperone protein conserved across all organisms. As a chaperone protein, it correctly folds client proteins. Structurally, this protein is a dimer with monomer subunits that consist of three main conserved domains known as the N ...
Bereket Birbo +4 more
semanticscholar +1 more source
HSP90 mediates the connection of multiple programmed cell death in diseases
Cell Death and Disease, 2022 Heat shock protein (HSP) 90, an important component of the molecular chaperone network, is closely concerned with cellular signaling pathways and stress response by participating in the process of maturation and activation of client proteins, playing a ...
Caiwang Peng +5 more
semanticscholar +1 more source
A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90
Disease Models & Mechanisms, 2022 Nrf2 is the master transcriptional regulator of cellular responses against oxidative stress. It is chiefly regulated by Keap1, a substrate adaptor protein that mediates Nrf2 degradation. Nrf2 activity is also influenced by many other protein interactions
Vy Ngo +5 more
doaj +1 more source