Results 101 to 110 of about 109,885 (301)

Quantitative Immunomorphological Analysis of Heat Shock Proteins in Thyroid Follicular Adenoma and Carcinoma Tissues Reveals Their Potential for Differential Diagnosis and Points to a Role in Carcinogenesis

Applied Sciences, 2019
Hsp27, Hsp60, Hsp70, and Hsp90 are chaperones that play a crucial role in cellular homeostasis and differentiation, but they may be implicated in carcinogenesis. Follicular neoplasms of the thyroid include follicular adenoma and follicular carcinoma. The
Alessandro Pitruzzella, Letizia Paladino, Alessandra Maria Vitale, Stefania Martorana, Calogero Cipolla, Giuseppa Graceffa, Daniela Cabibi, Sabrina David, Alberto Fucarino, Fabio Bucchieri, Francesco Cappello, Everly Conway de Macario, Alberto JL Macario, Francesca Rappa   +13 more
doaj   +1 more source

HSP90: Chaperone-me-not

Pathology & Oncology Research, 2013
With increasing understanding of the molecular basis of carcinogenesis, its progression and metastasis, the cancer therapy has shifted from empirical approaches to targeting specific molecules that regulate the complex network of signalling pathways for cell survival and proliferation.
J M, Patki, S S, Pawar
openaire   +2 more sources

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Polymorphisms of Bovine HSP90 and Their Implications in Beef Cattle Productivity [PDF]

, 2018
Production of beef cattle represents a $60 billion industry in the United States (USDA, 2015). The American beef cattle industry loses an estimated $370 million annually due to heat stress (St-Pierre, 2003).
Smith, Glynn G
core   +2 more sources

Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals [PDF]

, 2009
Peer reviewedPublisher ...
Brown, Alistair J. P., Leach, Michelle D., Nicholls, Susan, Priest, Claire L.   +3 more
core   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

HSP90-Dependent Upregulation of EZH2 Promotes Hypoxia/Reoxygenation-Induced Pyroptosis by Inhibiting miR-22 in Endothelial Cells

Journal of Inflammation Research, 2023
Paihe Deng, Huimin Hu Clinical Laboratory Medicine Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210011, People’s Republic of ChinaCorrespondence: Huimin Hu, Clinical Laboratory Medicine Center, The Second ...
Deng P, Hu H
doaj  

Heat shock protein 90 mediates the protective effects of vericiguat on myocardial ischemia/reperfusion injury by inhibiting toll-like receptor 4 and c-Jun N-terminal kinases [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): This study aimed to investigate whether vericiguat exerts a protective effect against myocardial ischemia-reperfusion injury (MIRI) by inhibiting toll-like receptor 4 (TLR4) and c-Jun N-terminal kinases (JNK) activation and whether heat ...
Sijie Pan, Junyan Chen, Dongxiao Wang, Jianjun Meng, Min Wang, Guoqiang Zhong, Zhi-Yu Zeng, Ronghui Tu   +7 more
doaj   +1 more source

Identification of the N-terminal Peptide Binding Site of Glucose-regulated Protein 94 [PDF]

, 2004
Because the stress protein GRP94 can augment presentation of peptides to T cells, it is important to define how it, as well as all other HSP90 family members, binds peptides.
Argon, Baker-LePain, Baker-LePain, Binder, Blachere, Blond-Elguindi, Breloer, Burkholder, Collins, Fontana, Gragerov, Imarai, Ishii, Kalkum, Liu, Meng, Nieland, Prendergast, Prodromou, Prodromou, Prodromou, Rai, Robert, Roe, Schagger, Scheibel, Scheibel, Schneidman-Duhovny, Schulte, Shields, Shields, Singh-Jasuja, Slavik, Smith, Soldano, Spee, Stebbins, Suto, Tamura, Vogen, Wassenberg, Wearsch, Wearsch, Zhang, Zhu   +44 more
core   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source