Results 121 to 130 of about 58,138 (243)

Preface to Hsp90

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
openaire   +3 more sources

Advancing Thermotolerance in Beans: Integrating Physiology, Genomics, and Breeding for Climate Adaptation

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Rising global temperatures increasingly threaten bean production and the food security of millions of people who depend on these protein‐rich legumes. Heat stress during the reproductive stages induces pollen sterility, flower abscission, and disruptions in source–sink relationships, resulting in yield losses of 30%–40% or more when critical ...
Aastha Sharda, Shikha Chaudhary, Bhawna Kumari, Uday C. Jha, Mohar Singh, Inderjit Singh, Kamal Dev Sharma, Kadambot H. M. Siddique, P. V. Vara Prasad, Harsh Nayyar   +9 more
wiley   +1 more source

CRISPR/Cas9‐Mediated Editing of Four Ca2+‐Binding Receptor‐Like Cytoplasmic Kinases Improves Soybean Seed Size and Yield at Dense Planting

Plant Biotechnology Journal, EarlyView.
Wanhong Li, Jun Jin, Tianyue Gu, Xiaoxi Cai, Bowei Jia, Yan Wang, Dezhi Han, Xiaofei Yan, Xiping Hu, Xiaoli Sun, Sijia Lu, Mingzhe Sun   +11 more
wiley   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tissues and that impaired AKT signalling is a major molecular driver of insulin resistance in obesity.
Natasha Jaiswal, Matthew Gavin, Louise Lantier, Olivia Yu Yu Ong, David H. Wasserman, Paul M. Titchenell   +5 more
wiley   +1 more source

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, Volume 138, Issue 29, 13 July 2026.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources

Immunoglobulin binding protein (BiP) forms two types of dimers

Protein Science, Volume 35, Issue 8, August 2026.
Abstract Immunoglobulin binding protein (BiP) is a chaperone protein that plays crucial roles in protein folding and transport by binding unfolded proteins in the substrate binding domain (SBD), an interaction allosterically linked to the nucleotide occupancy of the nucleotide binding domain (NBD).
Karina New, Miguel I. A. Lagos‐Espinoza, Nathalie Casanova‐Morales, Roi Asor, John William Young, Zahra Alavi, Christian A. M. Wilson   +6 more
wiley   +1 more source

Beyond Inhibition: Rebalancing the Hsp90 Chaperone Network as a Therapeutic Strategy for Alzheimer's Disease. [PDF]

Drug Des Devel Ther
Tang Z, Xie H, Xu Y, Zhou Z, Lu F, Wu Q, Liang W, Zhong M, Li S.   +8 more
europepmc   +1 more source

Dual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice

British Journal of Pharmacology, Volume 183, Issue 15, Page 4399-4415, August 2026.
Abstract Background and Purpose Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.
Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen   +15 more
wiley   +1 more source