Results 141 to 150 of about 76,334 (253)

Bioinformatics, chemoinformatics, and pharmainformatics analysis of HER2/HSP90 dual-targeted inhibitors

, 2012
[[abstract]]Heat shock protein 90 (HSP90) and human epidermal growth factor receptor 2 protein (HER2) are involved in several signal pathways for cancer cell proliferation.
陳語謙;Chen, Calvin Yu-Chian
core  

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source

HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma. [PDF]

Signal Transduct Target Ther
Li L, Zhang Y, Li M, Yang X, Chang G, Zhang W, Yan Y, Pan Y, Liang Y, Wang S, Wang M, Hoffman RM, Wei W, Jia L.   +13 more
europepmc   +1 more source

Unravelling Mechanisms of Acquired Drought Tolerance by Priming in Tomato Using Integrative Multi‐Omics Phenotypic Analysis

Plant Biotechnology Journal, EarlyView.
ABSTRACT The escalating frequency and intensity of recent droughts threaten global crop production and food security. Although drought priming is crucial for plant drought resilience, the mechanisms imparting drought stress memory remain poorly understood, especially in crops such as tomato. This study elucidates the mechanisms of drought stress memory
Rong Zhou, Yankai Li, Ge Wang, Hong Chen, Xiaqing Yu, Yinlei Wang, Xuedong Yang, Zhen Lyu, Trupti Joshi, Xiaoming Song, Carl‐Otto Ottosen, Ian Charles Dodd, Ron Mittler, Fangling Jiang, Zhen Wu   +14 more
wiley   +1 more source

Molecular Chaperone Networks in Plants: Maintaining Proteostasis and Enhancing Stress Resilience for Crop Improvement

Plant, Cell &Environment, EarlyView.
ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang, Anqin Gao, Tsz‐Yan Chan, Hafiz Mamoon Rehman, Sehar Nawaz, Sehrish Bashir, Noman Mahmood, Muhammad Wajid Ullah, Chunlin Long, Hon‐Ming Lam, Muhammad Arif   +10 more
wiley   +1 more source

Differential heat shock protein transcript expression in mouse lower urinary tract (LUT) pathways in cyclophosphamide (CYP)-induced cystitis or repeated variate stress (RVS). [PDF]

Auton Neurosci
Isenhour A, Roman A, Hambright E, Girard BM, Vizzard MA.   +4 more
europepmc   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

Phosphoregulierung der Hsp90 Chaperon Maschinerie

, 2012
Hsp90 is a molecular chaperone modulating the activity of hundreds of client proteins. This activation process is regulated on several levels: by ATP hydrolysis, various specific Hsp90 co-chaperones and posttranslational modifications.
Soroka, Joanna
core  

AHA1 Regulates Aβ Production via Modulation of APP Abundance and γ-Secretase Assembly. [PDF]

J Neurochem
Noorani AA, Islam S, Filip E, Catalfano K, Paswan S, Nagarajan V, Wilkins HM, Blagg BSJ, Zou K, Wolfe MS.   +9 more
europepmc   +1 more source

Understanding extracellular vesicle biology, isolation, and characterization: The theory of EV‐erything

Periodontology 2000, EarlyView.
Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad, Nima Farshidfar, Nathan E. Estrin, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +6 more
wiley   +1 more source