Results 71 to 80 of about 138,190 (352)

SERUM HSP 90 LEVELS OF CHRONIC HEPATITIS B PATIENTS ARE SUBSTANTIALLY CORRELATED WITH HBV DNA VIRAL LOAD [PDF]

Euromediterranean Biomedical Journal
The highly conserved molecules that make up the mammalian HSP90 family of proteins are engaged in a wide range of cellular functions. HSP90 and its co-chaperones regulate vital physiological processes as apoptosis, hormone signaling, and cell cycle ...
Awaz A. Saadi
doaj   +1 more source

Mitochondria‐Targeted Nanomotor: H2S‐Driven Cascade Therapy for Hepatocellular Carcinoma

Advanced Materials, EarlyView.
A mitochondrial‐targeted nanomotor integrates photodynamic therapy, mild photothermal therapy, and enzyme dynamic therapy into a self‐amplifying cascade through H2S‐driven metabolic reprogramming. Abstract Despite advances in combination therapies for cancer treatment, most strategies rely on modular‐additive designs that lack dynamic molecular cues to
Chengcheng Li, Xiaodong Ma, Shiji Fang, Biao Chen, Xinru Wang, Lingyun He, Xin Yang, Yuanqiang Li, Jessica M. Rosenholm, Zhongwei Zhao, Jiansong Ji, Hongbo Zhang   +11 more
wiley   +1 more source

FLEXR-MSA: electron-density map comparisons of sequence-diverse structures

IUCrJ
Proteins with near-identical sequences often share similar static structures. Yet, comparing crystal structures is limited or even biased by what has been included or omitted in the deposited model.
Timothy R. Stachowski, Marcus Fischer
doaj   +1 more source

Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Overexpression of heat shock protein 90 (Hsp90) is common in various types of cancer. In cutaneous melanoma, a cancer with one of the high levels of Hsp90 overexpression, such expression was correlated with a panel of protein kinases, thus offering an ...
Feifei Qin, Yali Wang, Xian Jiang, Yujia Wang, Nan Zhang, Xiang Wen, Lian Wang, Qinglin Jiang, Gu He   +8 more
doaj   +1 more source

New Insights on Heat Shock Proteins as Regulators of Reactive Oxygen Species Across Various Stressors in Diseases. [PDF]

Cell Biochem Funct
ABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Kumar PS, Kodi T, Gopinathan A, Byregowda BH, Nandakumar K, Kishore A.   +5 more
europepmc   +2 more sources

Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling

Journal of Biological Chemistry, 2018
Heat shock proteins 90 (Hsp90) and 70 (Hsp70) are two families of highly conserved ATP-dependent molecular chaperones that fold and remodel proteins. Both are important components of the cellular machinery involved in protein homeostasis and participate ...
Olivier Genest, S. Wickner, Shannon M. Doyle   +2 more
semanticscholar   +1 more source

Hsp90 interaction with clients

Trends in Biochemical Sciences, 2015
The conserved Hsp90 chaperone is an ATP-controlled machine that assists the folding and controls the stability of select proteins. Emerging data explain how Hsp90 achieves client specificity and its role in the cellular chaperone cascade. Interestingly, Hsp90 has an extended substrate binding interface that crosses domain boundaries, exhibiting ...
Karagoz, Elif, Rüdiger, Stefan G D
openaire   +3 more sources

ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication

Advanced Science, EarlyView.
During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou, Mingbin He, Jinhong Du, Cong Liu, Weiwei Wang, Yuewen Han, Zhifei Li, Yali Qin, Mingzhou Chen   +8 more
wiley   +1 more source

Targeting Plasmodium falciparum Hsp90: Towards Reversing Antimalarial Resistance

Pathogens, 2013
Malaria continues to exact a great human toll in tropical settings. Antimalarial resistance is rife and the parasite inexorably develops mechanisms to outwit our best drugs, including the now first-line choice, artesunate.
Dea Shahinas, Asongna Folefoc, Dylan R. Pillai   +2 more
doaj   +1 more source

Genome-Wide Characterization of HSP90 Gene Family in Cucumber and Their Potential Roles in Response to Abiotic and Biotic Stresses

Frontiers in Genetics, 2021
Heat shock protein 90 (HSP90) possesses critical functions in plant developmental control and defense reactions. The HSP90 gene family has been studied in various plant species.
Kaijing Zhang, Shuaishuai He, Yihu Sui, Qinghai Gao, Shuangshuang Jia, Xiaomin Lu, Li Jia   +6 more
doaj   +1 more source