Results 71 to 80 of about 108,942 (214)

Virulence of HtpG⁺ and HtpG⁻ strains of Yersinia pestis for Mice and Guinea Pigs

Проблемы особо опасных инфекций, 2020
HtpG (high-temperature protein G) is a bacterial homologue of the highly conserved molecular chaperone Hsp90 of eukaryotes, which plays an important role in protection against stress in many bacterial species.
E. A. Krasil’nikova, R. Z. Shaikhutdinova, T. E. Svetoch, M. E. Platonov, T. I. Kombarova, S. A. Ivanov, S. V. Dentovskaya, A. P. Anisimov   +7 more
doaj   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

The clickable activity-based probe of anti-apoptotic calenduloside E

Pharmaceutical Biology, 2019
Context: Calenduloside E (CE), one of the primary natural products found in Aralia elata (Miq.) Seem. (Araliaceae), possesses prominent anti-apoptotic potential.
Yu Tian, Shan Wang, Hai Shang, Wen-Qian Wang, Bao-Qi Wang, Xi Zhang, Xu-Dong Xu, Gui-Bo Sun, Xiao-Bo Sun   +8 more
doaj   +1 more source

A CRY-BIC negative-feedback circuitry regulating blue light sensitivity of Arabidopsis. [PDF]

, 2017
Cryptochromes are blue light receptors that regulate various light responses in plants. Arabidopsis cryptochrome 1 (CRY1) and cryptochrome 2 (CRY2) mediate blue light inhibition of hypocotyl elongation and long-day (LD) promotion of floral initiation. It
Gu, Lianfeng, Han, Yun-Jeong, He, Wenjin, Kim, Jeong-Il, Lin, Chentao, Liu, Bin, Liu, Bobin, Liu, Qing, Matsui, Minami, Oka, Yoshito, Su, Jun, Wang, Jian, Wang, Qin, Wang, Xu, Yang, Zhaohe, Zuo, Zecheng   +15 more
core   +2 more sources

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

Calcyclin Binding Protein/Siah-1 Interacting Protein Is a Hsp90 Binding Chaperone. [PDF]

PLoS ONE, 2016
The Hsp90 chaperone activity is tightly regulated by interaction with many co-chaperones. Since CacyBP/SIP shares some sequence homology with a known Hsp90 co-chaperone, Sgt1, in this work we performed a set of experiments in order to verify whether ...
Agnieszka Góral, Paweł Bieganowski, Wiktor Prus, Łucja Krzemień-Ojak, Beata Kądziołka, Hanna Fabczak, Anna Filipek   +6 more
doaj   +1 more source

Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm-blooded animals [PDF]

, 2009
Peer reviewedPublisher ...
Brown, Alistair J. P., Leach, Michelle D., Nicholls, Susan, Priest, Claire L.   +3 more
core   +1 more source

CRISPR/Cas9‐Based Vanadium MXene‐Free Radical Spatiotemporally Controlled Nanoreactor for Photothermal‐Induced Multi‐Effect Synergistic Antitumor Therapy

Advanced Science, EarlyView.
In this study, a MXene‐based V4C3 nanoplatform, VARH, was constructed, which achieved a photothermal conversion efficiency of 44.21% in the NIR‐II window. This platform integrated photothermal therapy, chemodynamic therapy, and thermodynamic therapy with CRISPR/Cas9‐mediated heat shock protein 90 knock‐out technology.
Zi‐Jian Huang, Feng‐Ming Li, Yi‐Fan Tu, Ke‐Ke Feng, Cheng‐Lei Li, Shi‐Cheng Tian, Yong‐Shan Hu, Jing‐Wei Shao, Zhen‐Hua Liu   +8 more
wiley   +1 more source

Unveiling the antiglioblastoma potential of harmicens, harmine and ferrocene hybrids

Acta Pharmaceutica
The poor prognosis of glioblastoma multiforme, inadequate treatment options, and growing drug resistance urge the need to find new effective agents. Due to the significant anti-cancer potential of harmicens, hybrid compounds which comprise harmine/β ...
Poje Goran, Šakić Davor, Marinović Marina, You Jiangyang, Tarpley Michael, Williams Kevin P., Golub Nikolina, Dernovšek Jaka, Tomašič Tihomir, Bešić Erim, Rajić Zrinka   +10 more
doaj   +1 more source

HSP90: A potential drug target in inflammatory skin diseases

JEADV Clinical Practice, 2023
Heat shock protein 90 (HSP90) is a chaperone protein belonging to the HSP family. HSP90 modulates clients by stabilising, folding, maturing, and tagging clients for proteasomal degradation.
A. H. Rittig, A. Bregnhøj, C. Johansen, L. Iversen   +3 more
doaj   +1 more source