Results 271 to 280 of about 21,325,054 (309)

HSV-1-inducible proteins bind to NF-κB-like Sites in the HSV-1 genome

Virology, 1992
Several putative NF-kappa B-binding sites in the ICP0 and Vmw65 herpes simplex virus type-1 (HSV-1) genes have been identified. Oligonucleotides encoding some of these sites bind specifically to purified NF-kappa B protein and an NF-kappa B-like protein in nuclear extracts of phorbol ester- or cycloheximide-induced human embryonic lung (HEL) cells. HSV-
B L, Rong, T A, Libermann, K, Kogawa, S, Ghosh, L X, Cao, D, Pavan-Langston, E C, Dunkel   +6 more
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Modification of HSV-1 to an Oncolytic Virus

2014
Cancer-permissive viruses or oncolytic viruses consist of either genetically engineered or naturally occurring strains that possess relatively selective replicative and/or infection abilities for cancer vs. normal cells (Chiocca, Nat Rev Cancer 2: 938-950, 2002).
Hiroshi, Nakashima, E Antonio, Chiocca
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HSV-1 genome sequencing

2023
HSV-1 genome sequence of two ...
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Immunization with a nonpathogenic HSV-1 strain prevents clinical and neuroendocrine changes of experimental HSV-1 encephalitis

Journal of Neuroimmunology, 2004
We examined whether immunization with the nonpathogenic strain R-15 of herpes simplex virus-1 (HSV-1) may prevent the clinical and neuroendocrine changes induced by the pathogenic HSV-1 strain Syn17+. Inoculation of strain Syn17+ to control rats induced fever, marked motor hyperactivity and aggressive behavior, and increased serum ACTH, corticosterone (
Tamir, Ben-Hur, Anna, Itzik, Ohr, Barak, Yael, Asher, Yechiel, Becker, Raz, Yirmiya, Joseph, Weidenfeld   +6 more
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HSV-1 Biology and Life Cycle

2014
Herpes simplex virus type 1 (HSV-1) is a common and important human pathogen that has been studied in a wide variety of contexts for several decades. This book presents chapters on protocols on many strands of HSV-1 research that are currently in use in leading laboratories.
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Latent HSV-1 infection in mice immunized with a zwitterionic detergent-extracted HSV-1 antigen preparation

Archives of Virology, 1989
A HSV-1 antigen preparation obtained by zwitterionic detergent-extraction of HSV-1 infected Vero cells was investigated for its ability to protect mice against establishment of latent infection in the trigeminal ganglion following HSV-1 challenge by ear scarification.
A, al-Ghamdi, R, Jennings, H, Bentley, C W, Potter   +3 more
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HSV-1 deamidates cGAS

Science Signaling, 2018
An HSV-1 enzyme represses innate immune responses by deamidating the cytosolic DNA sensor cGAS.
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Characterization of Extracellular HSV-1 Virions by Proteomics

2014
The analysis of herpes simplex virus type 1 mature extracellular virions by proteomics requires highly enriched samples to limit false positives and favor the detection of true components. The protocol described below involves the removal of highly contaminating serum proteins and purification of the virions by a series of differential and density ...
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HSV-1 Amplicon Vectors as Genetic Vaccines

2014
HSV-1 amplicon vectors have been used as platforms for the generation of genetic vaccines against both DNA and RNA viruses. Mice vaccinated with such vectors encoding structural proteins from both foot-and-mouth disease virus and rotavirus were partially protected from challenge with wild-type virus (D'Antuono et al.
Laimbacher, A S, Fraefel, C
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Engineering HSV-1 Vectors for Gene Therapy

2019
Virus vectors have been employed as gene transfer vehicles for various preclinical and clinical gene therapy applications and with the approval of Glybera (Alipogene tiparvovec) as the first gene therapy product as a standard medical treatment (Yla-Herttuala, Mol Ther 20:1831-1832, 2013), gene therapy has reached the status of being a part of standard ...
William F, Goins, Shaohua, Huang, Bonnie, Hall, Marco, Marzulli, Justus B, Cohen, Joseph C, Glorioso   +5 more
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