Results 111 to 120 of about 17,745,525 (306)

Membrane‐Permeable Nucleoside T‐1106 Diphosphate and Triphosphate Analogues as Antiviral Pronucleotides

Chemistry – A European Journal, EarlyView.
Favipiravir (T‐705) and the non‐fluorinated counterpart (T‐1106) are antiviral agents that inhibit the RNA‐dependent RNA polymerase (RdRp) of various RNA viruses. The antiviral efficacy of nucleoside analogues is strongly dependent on their intracellular activation by cellular kinases to produce their corresponding triphosphate metabolites (T‐705‐RTP ...
Chris Meier, Duan Li, Leentje Persoons, Graciela Andrei, Robert Snoeck, Dominique Schols, Lieve Naesens, Xiao Jia   +7 more
wiley   +1 more source

Aqueous Supercapacitor with Wide‐Temperature Operability and over 100,000 Cycles Enabled by Water‐in‐Salt Electrolyte

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
This study presents a symmetric supercapacitor with activated carbon electrodes and a “water‐in‐salt” electrolyte (WiSE) based on lithium perchlorate, offering over 100,000 cycles with over 90 % capacity retention. The supercapacitor operates efficiently from −20 to 80 °C, enhancing performance, stability, and all‐season operability.
Zahid Ali Zafar, Radim Weisser, Ghulam Abbas, Martin Silhavik, Prabhat Kumar, Jiří Červenka   +5 more
wiley   +1 more source

An investigation of herpes simplex virus promoter activity compatible with latency establishment reveals VP16-independent activation of immediate-early promoters in sensory neurones [PDF]

, 2011
Herpes simplex virus (HSV) type-1 establishes lifelong latency in sensory neurones and it is widely assumed that latency is the consequence of a failure to initiate virus immediate-early (IE) gene expression. However, using a Ore reporter mouse system in
Heather M. Coleman, Connor, V., Proenca, J.T., Michael P. Nicoll, Nicoll, M.P., Jane Arthur, Arthur, J., Preston, C.M., João T. Proença, Christopher M. Preston, Coleman, H.M., Efstathiou, S., Stacey Efstathiou, Viv Connor   +13 more
core   +1 more source

Real‐world outcomes of responsive neurostimulation in patients with Lennox–Gastaut syndrome: A multicenter retrospective study

Epilepsia Open, EarlyView.
Abstract Objective Lennox–Gastaut syndrome (LGS) is a severe developmental and epileptic encephalopathy (DEE) characterized by multiple seizure types and high resistance to antiseizure medication (ASM), often necessitating nonpharmacologic therapies, including neuromodulation.
Shanna M. Swartwood, Robert J. Bollo, Catherine J. Chu, Alexandra L. Geffrey, Robert Mark Richardson, Hiroki Nariai, Aria Fallah, Samuel Ahn, Saadi Ghatan, Laura Chenevert, Maite La Vega‐Talbott, Audie C. Espinoza   +11 more
wiley   +1 more source

Immunization with a highly attenuated replication-competent herpes simplex virus type 1 mutant, HF10, protects mice from genital disease caused by herpes simplex virus type 2

Frontiers in Microbiology, 2012
Genital herpes is an intractable disease caused mainly by herpes simplex virus type 2 (HSV-2), and is a major concern in public health. A previous infection with HSV type 1 (HSV-1) enhances protection against primary HSV-2 infection to some extent.
Chenhong eLuo, Fumi eGoshima, Maki eKamakura, Yoshifumi eMutoh, Seiko eIwata, Hiroshi eKimura, Yukihiro eNishiyama   +6 more
doaj   +1 more source

HSV-1 envelope proteins and their roles in entry and membrane fusion.

, 2019
(A) HSV-1 entry into cells requires the coordinated efforts of the receptor-binding glycoprotein gD (RCSB PDB: 2C36), the heterodimer gH/gL (RCSB PDB: 3M1C), and the fusogen gB (RCSB PDB: 5V2S).
Ekaterina E. Heldwein (815959), Adam T. Hilterbrand (6685169)   +1 more
core   +1 more source

Nano‐Silver‐Selenium Liquid Dressing Facilitates Treatment of Monkeypox and Prevention of Viral Transmission in a Surrogate Mouse Model

Exploration, EarlyView.
There is no effective method to treat this virus and prevent its transmission. To address this, we have developed a nano‐silver‐selenium liquid dressing (AgSe@LD) by combining silver and selenium nanoparticles with commercial liquid dressings. This unique AgSe@LD formulation exhibits good adhesion, stability and toughness and demonstrates efficient ...
Wei Wang, Mengjun Li, Zining Liu, Jiayin Chen, Ke Liu, Fengfang Wei, Junrui Li, Yixuan Xie, Yushan Jiang, Tyuji Hoshino, Vladislav Victorovich Khrustalev, Minghui Yang, Hua Ma, Ruilin Zhang, Chenguang Shen, Yuhui Liao   +15 more
wiley   +1 more source

Seroepidemiology of Herpes Simplex Viruses Type 1 and 2 in Pregnant Women in Croatia

Medicina
Background and Objectives: Herpes simplex viruses (HSV-1 and HSV-2) are one of the most widespread causes of human viral infections. In Croatia, only two published studies have analyzed the seroprevalence of HSV infections in childbearing-aged and ...
Tatjana Vilibic-Cavlek, Marko Belamaric, Thomas Ferenc, Dan Navolan, Branko Kolaric, Ljiljana Milasincic, Ljiljana Antolasic, Mateja Vujica Ferenc, Maja Vilibic, Adriana Lukunic, Maja Bogdanic   +10 more
doaj   +1 more source

Detection, quantification and genotyping of Herpes Simplex Virus in cervicovaginal secretions by real-time PCR: a cross sectional survey

Virology Journal, 2005
Background Herpes Simplex Virus (HSV) Genital Ulcer Disease (GUD) is an important public health problem, whose interaction with HIV results in mutually enhancing epidemics. Conventional methods for detecting HSV tend to be slow and insensitive.
Natividad-Sancho Angels, Bailey Robin L, Aryee Esther AN, Kaye Steve, Holland Martin J   +4 more
doaj   +1 more source

Avaliação da ação anti-herpética de llex paraguariensis A. St. Hil., Aquifoliaceae (erva-mate) [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2009Os Herpes Simplex Virus tipos 1 e 2 (HSV-1 e HSV-2) são vírus envelopados de DNA, que causam várias ...
Lückemeyer, Débora Denardini
core