Results 261 to 270 of about 112,416,099 (307)

Development of a microneutralization assay for HSV-2

Journal of Virological Methods, 2021
Plaque Reduction Neutralization Test (PRNT) is the standard assay used for measuring neutralizing antibody responses to Herpes simplex virus type-2 (HSV-2). The PRNT is a cumbersome, time-consuming and laborious assay. The development of a faster, high throughput microneutralization assay (MNA) for HSV-2 viruses carried out in a 96-well format will ...
Melanie S. Horton, Michael Minnier, Scott Cosmi, Kara Cox, Jennifer Galli, Jessica Peters, Nicole Sullivan, Brian Squadroni, Aimin Tang, Arthur Fridman, Dai Wang, Zhifeng Chen, Kalpit A. Vora   +12 more
openaire   +2 more sources

Daily Acyclovir to Decrease Herpes Simplex Virus Type 2 (HSV-2) Transmission From HSV-2/HIV-1 Coinfected Persons: A Randomized Controlled Trial

Journal of Infectious Diseases, 2013
BACKGROUND: Daily suppressive therapy with valacyclovir reduces risk of sexual transmission of herpes simplex virus type 2 (HSV-2) in HSV-2-serodiscordant heterosexual couples by 48%.
Amalia S Magaret, Lawrence Corey, Grace John-Stewart   +2 more
exaly   +2 more sources

HSV-2 transmission

Antiviral Research, 2004
A number of important risk factors for the acquisition of HSV-2 have been established including female gender, black or Hispanic ethnic origin, HIV infection, age, and increased number of sexual partners. Transmission is influenced by a number of biological factors such as sexual behavior, use of condoms, duration of relationships, and knowledge of a ...
S L, Sacks, P D, Griffiths, L, Corey, C, Cohen, A, Cunningham, G M, Dusheiko, S, Self, S, Spruance, L R, Stanberry, A, Wald, R J, Whitley   +10 more
openaire   +2 more sources

Modeling the synergy between HSV-2 and HIV and potential impact of HSV-2 therapy

Mathematical Biosciences, 2013
Mounting evidence indicates that genital HSV-2 infection may increase susceptibility to HIV infection and that co-infection may increase infectiousness. Accordingly, antiviral treatment of people with HSV-2 may mitigate the incidence of HIV in populations where both pathogens occur. To better understand the epidemiological synergy between HIV and HSV-2,
Feng, Zhilan, Qiu, Zhipeng, Sang, Zi, Lorenzo, Christina, Glasser, John   +4 more
openaire   +3 more sources

Seroprevalence of HSV-2 in Hungary and comparison of the HSV-2 prevalence of pregnant and infertile women

Acta Microbiologica et Immunologica Hungarica, 2008
Herpes simplex virus type 2 infection is a quite common but frequently asymptomatic, therefore undiagnosed condition. Genital HSV-2 infection may cause neonatal herpes, enhances HIV transmission and may play a role in infertility. To evaluate the prevalence of HSV-2 in Hungary we tested 2500 serum samples for the presence of anti-HSV-2 IgG by ELISA ...
Hettmann, Andrea, Gerle, Borbála, Barcsay, Erzsébet, Csiszár, Csenge, Takács, Mária   +4 more
openaire   +3 more sources

Psychosocial Impact of a Positive HSV‐2 Diagnosis on Adults with Unrecognized HSV‐2 Infection

Public Health Nursing, 2011
ABSTRACT Objective: To evaluate the current research on the psychosocial impact of a positive herpes simplex virus type 2 (HSV‐2) diagnosis on asymptomatic adults.Design and Sample: A structured review of PubMed, CINAHL, and MEDLINE resulted in 8 articles published between 2000 and 2008.Measures: Articles were included if they investigated ...
Allison, Provenzale, Kara, Evans, Julie, Russell, Tammy, Hoory, Hayley, Mark   +4 more
openaire   +2 more sources

Safety and immunogenicity of long HSV-2 peptides complexed with rhHsc70 in HSV-2 seropositive persons

Vaccine, 2011
HSV-2, the primary causative agent of genital herpes, establishes latency in sensory ganglia and reactivates causing recurrent lesions and viral shedding. Induction or expansion of CD4(+) and CD8(+) T cell responses are expected to be important for a successful therapeutic vaccine against HSV-2.
Anna, Wald, David M, Koelle, Kenneth, Fife, Terri, Warren, Kenneth, Leclair, Roman M, Chicz, Stephen, Monks, Daniel L, Levey, Cristina, Musselli, Pramod K, Srivastava   +9 more
openaire   +2 more sources

Homology of the HSV-2 ?a-sequence? to cellular sequences

Virus Genes, 1988
Bgl-II fragments of the genome of Herpes simplex virus type 2 (HSV-2) HG-52 were cloned into the vector p-Neo and were used to screen the complete HSV-2 genome for regions cross-hybridizing with the genome of HEL cells. Most extensive cross-hybridizing activity was observed with a 530 bp SstII subfragment of the viral BamHI G DNA-fragment (contained in
E, Kohler, J, Kühn, K, Munk, R, Braun
openaire   +2 more sources

Development of a therapeutic vaccine for HSV-2

Vaccine, 2005
A therapeutic vaccine for genital herpes is clearly needed. Vaccines recently developed for HSV-2 in humans have been aimed at eliciting CD4+ T cell responses and neutralizing antibody responses to two HSV-2 glycoproteins (gB and gD). These vaccines have had no therapeutic effect against HSV-2 in human clinical trials.
openaire   +2 more sources

VAGINAL IMMUNITY IN THE HSV-2 MOUSE MODEL

International Reviews of Immunology, 2003
Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract. Efforts to develop vaccines to protect women against this and other sexually transmitted pathogens would be facilitated by a better understanding of the immune mechanisms that protect the female reproductive tract against such infections.
Margaret B, Parr, Earl L, Parr
openaire   +2 more sources