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Human T-cell lymphotropic virus type 1 (HTLV-1) is the first retrovirus described as a causative agent of human disease. Following adult T-cell leukemia/lymphoma and HLTV-1-associated myelopathy/tropical spastic paraparesis, HTLV-1 uveitis has been ...
Koju eKamoi, Manabu eMochizuki
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Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication [PDF]
Abstract Human T lymphotropic virus type 1 (HTLV-1) belongs to the deltaretrovirus family and has been linked to multiple diseases. However, the innate host defense against HTLV-1 is unclear. In this study, we report that the expression of Ku70, a known DNA sensor against DNA viruses, could be induced by HTLV-1 infection in HeLa, PMA ...
Jie Wang +9 more
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A 53-year-old woman developed subacute onset of upper limb weakness, sensory loss and cerebellar dysfunction. She was known to have human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy. MR scan of the brain showed extensive T2 hyperintensity within the deep and subcortical white matter, with punctate contrast enhancement.
King-Robson, J +4 more
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Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus described as a causative agent for human disease. In the field of ophthalmology, a close relationship between HTLV-1 infection and uveitis was identified through a series of clinical and laboratory studies in the late 1980s-1990s.
Koju Kamoi, Koju Kamoi, Koju Kamoi
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The years 2020 and 2021 will remain memorable years for many reasons [...]
Journo, Chloé, Martin, Fabiola
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Regulation of HTLV-1 transformation [PDF]
AbstractHuman T-cell leukemia virus type 1 (HTLV-1) is the only identified oncogenic human retrovirus. HTLV-1 infects approximately 5–10 million people worldwide and is the infectious cause of adult T-cell leukemia/lymphoma (ATL) and several chronic inflammatory diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP ...
Kyle J. Ernzen, Amanda R. Panfil
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HTLV-1 and Co-infections [PDF]
Human T lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes lifelong T-cell infection in humans, impacting the host immune response. This virus causes a range of clinical manifestations, from inflammatory conditions, including neuronal damage (HTLV-1 associated myelopathy, HAM) to life-threatening leukemia (adult T-cell leukemia, ATL). Human
Carolina Rosadas +2 more
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Subtype Analysis of HTLV‐1 in Patients with HTLV‐1 Uveitis [PDF]
The hypothesis that HTLV‐1 uveitis, a recently identified disease entity associated with human T‐cell leukemia virus type I (HTLV‐1), is caused by a specific subtype of the virus was tested. The nucleotide sequences of the long terminal repeat of HTLV‐1 from five patients with HTLV‐1 uveitis (HU) and four with adult T‐cell leukemia were ...
Ono, Ayako +8 more
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Vertical Transmission of HTLV‐1 in HTLV‐1 Carrier Rat [PDF]
A female F344 rat was injected with 2.4 × 106 MT‐2 cells intravenously at 3 and 4 weeks old, and was mated with a non‐infected male rat at the 17th week after injection, when the dam rat contained HTLV‐1 provirus in the peripheral blood mononuclear cells as determined by polymerase chain reaction.
Ami, Yoshihiro +10 more
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Plasma proteome analysis in HTLV-1-associated myelopathy/tropical spastic paraparesis [PDF]
Background: Human T lymphotropic virus Type 1 (HTLV-1) causes a chronic inflammatory disease of the central nervous system known as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM) which resembles chronic spinal forms of multiple ...
Stumpf, M. P. H. (Michael P. H.) +43 more
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