Results 21 to 30 of about 22,246,700 (213)

ADAR1 enhances HTLV-1 and HTLV-2 replication through inhibition of PKR activity [PDF]

Retrovirology, 2014
The role of innate immunity in general and of type I interferon (IFN-I) in particular in HTLV-1 pathogenesis is still a matter of debate. ADAR1-p150 is an Interferon Stimulated Gene (ISG) induced by IFN-I that can edit viral RNAs. We therefore investigated whether it could play the role of an anti-HTLV factor.We demonstrate here that ADAR1 is also ...
Cachat, Anne, Alais, Sandrine, Chevalier, Sébastien Alain, Journo, Chloé, Fusil, Floriane, Dutartre, Hélène, Boniface, Adrien, Ko, Nga Ling, Gessain, Antoine, François-Loïc, Cosset, Suspène, Rodolphe, Vartanian, Jean Pierre, Mahieux, Renaud   +12 more
openaire   +5 more sources

The MHC-II transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators [PDF]

Frontiers in Microbiology, 2013
The activation of CD4(+) T helper cells is strictly dependent on the presentation of antigenic peptides by MHC class II (MHC-II) molecules. MHC-II expression is primarily regulated at the transcriptional level by the AIR-1 gene product CIITA (class II ...
Abdallah, R., Accolla, Roberto, Forlani, Greta, Tosi, Giovanna   +3 more
core   +3 more sources

Rheumatological Manifestations in People Living with Human T-Lymphotropic Viruses 1 and 2 (HTLV-1 and HTLV-2) in Northern Brazil [PDF]

Viruses
Human T-lymphotropic virus 1 (HTLV-1) infection has been associated with inflammatory, autoimmune, and lymphoproliferative diseases with a wide spectrum of clinical manifestations.
Márcio Yutaka Tsukimata, Bianca Lumi Inomata da Silva, Leonn Mendes Soares Pereira, Bruno José Sarmento Botelho, Luciana Cristina Coelho Santos, Carlos David Araújo Bichara, Gabriel dos Santos Pereira Neto, Aline Cecy Rocha Lima, Francisco Erivan da Cunha Rodrigues, Natália Pinheiro André, Sarah Marques Galdino, Danniele Chagas Monteiro, Ludmila do Carmo de Souza Silva, Lourena Camila Oliveira Araújo, José Ronaldo Matos Carneiro, Rosana de Britto Pereira Cruz, Ricardo Ishak, Antonio Carlos Rosário Vallinoto, Bárbara Nascimento de Carvalho Klemz, Izaura Maria Vieira Cayres Vallinoto   +19 more
doaj   +2 more sources

Functional comparison of antisense proteins of HTLV-1 and HTLV-2 in viral pathogenesis [PDF]

Frontiers in Microbiology, 2013
The production of antisense transcripts from the 3' long terminal repeat (LTR) in human T-lymphotropic retroviruses has now been clearly demonstrated. After the identification of the antisense strand-encoded human T-lymphotropic virus type 1 (HTLV-1) bZIP (HBZ) factor, we reported that HBZ could interact with CRE-binding protein (CREB) transcription ...
Barbeau, Benoit, Peloponese, Jean-Marie, Mesnard, Jean-Michel   +2 more
openaire   +5 more sources

Trends in the prevalence and distribution of HTLV-1 and HTLV-2 infections in Spain

Virology Journal, 2012
Background Although most HTLV infections in Spain have been found in native intravenous drug users carrying HTLV-2, the large immigration flows from Latin America and Sub-Saharan Africa in recent years may have changed the prevalence and distribution of ...
Treviño Ana, Aguilera Antonio, Caballero Estrella, Benito Rafael, Parra Patricia, Eiros Jose M, Hernandez Araceli, Calderón Enrique, Rodríguez Manuel, Torres Alvaro, García Juan, Ramos Jose, Roc Lourdes, Marcaida Goitzane, Rodríguez Carmen, Trigo Matilde, Gomez Cesar, de Lejarazu Raul, de Mendoza Carmen, Soriano Vincent   +19 more
doaj   +2 more sources

Gut Microbiome Dysbiosis is Associated With Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection and Disease Progression to HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Cross-Sectional Study. [PDF]

Smart Med
We provide the first comprehensive analysis of changes in the gut bacteriome at different clinical stages of HTLV‐1 infection. HTLV‐1 infection is associated with a dysbiosis that includes reduced bacterial diversity and an inverted Firmicutes/Bacteroidetes ratio.
Fernandes LA, de Souza AO, Nukui Y, Marcusso RM, de Oliveira ACP, Casseb J, Clissa PB, Villas-Boas SG, Sanabani SS.   +8 more
europepmc   +2 more sources

HTLV-1 and HTLV-2 Infection Among Warao Indigenous Refugees in the Brazilian Amazon: Challenges for Public Health in Times of Increasing Migration. [PDF]

Front Public Health, 2022
Introduction Human T-lymphotropic virus (HTLV) infection is endemic in indigenous populations of the Americas. We describe herein the prevalence of HTLV-1 and HTLV-2 infection among Warao indigenous refugees from Venezuela living in Belém, Pará, Brazil ...
Abreu IN, Lopes FT, Lima CNC, Barbosa ADN, de Oliveira LR, Fujishima MA, Freitas FB, Dos Santos MB, de Lima VN, Cayres-Vallinoto IMV, Castelo-Branco S, da Silva HP, Vallinoto ACR.   +12 more
europepmc   +2 more sources

Biochemical Characterization, Specificity and Inhibition Studies of HTLV-1, HTLV-2, and HTLV-3 Proteases. [PDF]

Life (Basel), 2021
The human T-lymphotropic viruses (HTLVs) are causative agents of severe diseases including adult T-cell leukemia. Similar to human immunodeficiency viruses (HIVs), the viral protease (PR) plays a crucial role in the viral life-cycle via the processing of
Kassay N, Mótyán JA, Matúz K, Golda M, Tőzsér J.   +4 more
europepmc   +2 more sources

HTLV-1 and HTLV-2 Prevalence in the United States [PDF]

Journal of Infectious Diseases, 2013
Lucy B M, Cook, Graham P, Taylor
openaire   +3 more sources

HTLV-2 Encoded Antisense Protein APH-2 Suppresses HIV-1 Replication. [PDF]

Viruses, 2021
Antisense protein of Human T-cell Leukemia Virus Type 2 (HTLV-2), also called APH-2, negatively regulates the HTLV-2 and helps the virus to maintain latency via scheming the transcription. Despite the remarkable occurrence of HTLV-2/HIV-1 co-infection, the role of APH-2 influencing HIV-1 replication kinetics is poorly understood and needs investigation.
Londhe R, Kulkarni S.
europepmc   +5 more sources