Results 51 to 60 of about 43,354 (271)

Progressive loss of CD3 expression after HTLV-I infection results from chromatin remodeling affecting all the CD3 genes and persists despite early viral genes silencing [PDF]

, 2007
BACKGROUND: HTLV-I infected CD4+ T-cells lines usually progress towards a CD3- or CD3low phenotype. In this paper, we studied expression, kinetics, chromatin remodeling of the CD3 gene at different time-points post HTLV-I infection. RESULTS: The onset of
Haidar Akl, Bassam Badran, Gratiela Dobirta, Germain Manfouo-Foutsop, Maria Moschitta, Makram Merimi, Arsène Burny, Philippe Martiat, Karen E Willard-Gallo   +8 more
core   +1 more source

HTLV‐1 Tax Reshapes the DNA‐Binding Pattern of Transcription Factor IRF4 and Disrupts Host Gene Regulation

Cancer Science, EarlyView.
Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka, Jun Mizuike, Motomu Yano, Kaoru Uchimaru, Makoto Yamagishi   +4 more
wiley   +1 more source

HTLV-I Infection: Virus structure, Immune Response to the Virus and Genetic Association Studies in HTLV-I-Infected Individuals

Iranian Journal of Allergy, Asthma and Immunology, 2006
Although the structure of human T lymphoptropic virus type I (HTLV-I) has been known well, the function of some proteins encoded by HTLV-I PX region is not fully understood.
Houshang Rafatpanah, Reza Farid, Gelareh Golanbar, Farahzad Jabbari Azad   +3 more
doaj  

Mortality associated with HIV-1, HIV-2, and HTLV-I single and dual infections in a middle-aged and older population in Guinea-Bissau

Retrovirology, 2007
Background In Guinea-Bissau HIV-1, HIV-2, and HTLV-I are prevalent in the general population. The natural history of HIV/HTLV-I single and dual infections has not been fully elucidated in this population.
Larsen Olav, Vastrup Pernille, da Silva Zacarias, Holmgren Birgitta, Andersson Sören, Ravn Henrik, Aaby Peter   +6 more
doaj   +1 more source

Plasma Elastase Screening in Hematological Disease Reveals Its Potential as a Diagnostic and Prognostic Biomarker in Hematological Malignancies

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Neutrophil‐extracellular traps are net‐like material released by triggered neutrophils and composed of decondensed chromatin linked to nuclear proteins. Elastase, one of the fourth most represented neutrophil‐specific serine proteases stored in azurophil granules of naïve neutrophils, exerts various actions, including degradation ...
Pasqualina Scala, Anna Maria Della Corte, Angela Bertolini, Marisa Gorrese, Francesca Picone, Bianca Serio, Danilo De Novellis, Laura Mettivier, Luca Pezzullo, Maria Carmen Martorelli, Denise Morini, Matteo D'Addona, Bianca Cuffa, Carmine Selleri, Valentina Giudice   +14 more
wiley   +1 more source

Human T-cell Leukemia Virus Type 1 and Strongyloides stercoralis: Partners in Pathogenesis

Pathogens, 2020
Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated with various clinical syndromes including co-infection with Strongyloides stercoralis, which is an intestinal parasitic nematode and the leading cause of ...
Adam Dykie, Tharaka Wijesinghe, Arnold B. Rabson, Kiran Madugula, Christian Farinas, Sydney Wilson, David Abraham, Pooja Jain   +7 more
doaj   +1 more source

The tax-inducible actin-bundling protein fascin is crucial for release and cell-to-cell transmission of human T-cell leukemia virus type 1 (HTLV-1) [PDF]

, 2016
The delta-retrovirus Human T-cell leukemia virus type 1 (HTLV-1) preferentially infects CD4(+) T-cells via cell-to-cell transmission. Viruses are transmitted by polarized budding and by transfer of viral biofilms at the virological synapse (VS ...
Gettemans, Jan, Gross, Christine, Kalmer, Martina, Millen, Sebastian, Thoma-Kress, Andrea K, Wiesmann, Veit, Wittenberg, Thomas   +6 more
core   +6 more sources

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Encephalomyelopathy associated with HTLV-I: A primary disease or coexisting with multiple sclerosis?

Dementia & Neuropsychologia
HTLV-I-associated myelopathy (HAM/TSP) is the most common neurological manifestation of HTLV-I, causing progressive weakness, sensory disturbance, and sphincter dysfunction.
Ana Paula Silva Champs, Valéria Maria de Azeredo Passos, Sandhi Maria Barreto, Paulo Caramelli, Carla Meirelles de Melo, Guilherme Carvalho, Miriam Melo Menezes, João Gabriel Ramos Ribas   +7 more
doaj   +1 more source

Human T Cell Lymphotrophic virus infection among sexually active individuals in Nigeria: A cross sectional study

Scientific African, 2019
Introduction: Human T Cell Lymphotrophic virus (HTLV) is endemic in many regions of the world including Nigeria but not ubiquitous. It has been shown to be causally associated with T cell leukaemia and other myelopathies.
Babatunde Olusola, Adedayo Faneye, Yewande Nejo, Adewale Opayele, Solomon Bakarey   +4 more
doaj   +1 more source