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Network hub gene detection using the entire solution path information. [PDF]

Genetics
Kuismin M, Sillanpää MJ.
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Association analysis of hepatocellular carcinoma‐related hub proteins and hub genes

PROTEOMICS – Clinical Applications, 2023
AbstractPurposeHepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The occurrence and development of HCC are closely related to epigenetic modifications. Epigenetic modifications can regulate gene expression and related functions through DNA methylation.
Xinhong Zhang, Boyan Zhang, Yawei Zhang, Fan Zhang   +3 more
openaire   +2 more sources

Weighted gene co-expression network analysis identifies genes related to anthocyanin biosynthesis and functional verification of hub gene SmWRKY44.

Plant Science, 2021
Eggplant is rich in anthocyanins, which are thought to be highly beneficial for human health. There is no study on weighted gene co-expression network analysis (WGCNA) of anthocyanin biosynthesis in eggplant.
Yongjun He, Zhao-Wei Wang, Hai-Yan Ge, Yang Liu, Huoying Chen   +4 more
semanticscholar   +1 more source

Verification of Ferroptosis and Pyroptosis and Identification of PTGS2 as the Hub Gene in Human Coronary Artery Atherosclerosis.

Free Radical Biology & Medicine, 2021
Ferroptosis and pyroptosis have not been fully studied in atherosclerosis. We aimed to investigate the expression of ferroptosis-related and pyroptosis-related proteins in human coronary arteries and analyse correlation with severity of atherosclerosis ...
Yaqing Zhou, Hanxiao Zhou, Lei Hua, Can Hou, Qiaowei Jia, Jiaxin Chen, Shenmin Zhang, Yanjun Wang, Shu He, En-Zhi Jia   +9 more
semanticscholar   +1 more source

Interleukin 2 receptor subunit beta as a novel hub gene plays a potential role in the immune microenvironment of abdominal aortic aneurysms.

Gene, 2022
BACKGROUND Abdominal aortic aneurysm (AAA) is potentially life threatening and characterized by immune-inflammatory cell infiltration and extracellular matrix degradation.
Haoyu Gao, Luchen Wang, Jie Ren, Yanxiang Liu, Shenghua Liang, Bowen Zhang, Xiao-Gang Sun   +6 more
semanticscholar   +1 more source

CHEK1: a hub gene related to poor prognosis for lung adenocarcinoma.

Biomarkers in Medicine, 2021
Aim: The study aims to pinpoint hub genes and investigate their functions in order to gain insightful understandings of lung adenocarcinoma (LUAD). Methods: Bioinformatic approaches were adopted to investigate genes in databases including Gene Expression
Z. Tan, Min Chen, Ying Wang, Feng Peng, Xiaopeng Zhu, Xin Li, Lei Zhang, Ying Li, Ya-Jie Liu   +8 more
semanticscholar   +1 more source

RANKING DIFFERENTIAL HUBS IN GENE CO-EXPRESSION NETWORKS

Journal of Bioinformatics and Computational Biology, 2012
Identifying the genes that change their expressions between two conditions (such as normal versus cancer) is a crucial task that can help in understanding the causes of diseases. Differential networking has emerged as a powerful approach to detect the changes in network structures and to identify the differentially connected genes among two networks ...
Omar Odibat, Chandan K. Reddy
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The associations of hub gene polymorphisms in PI3K/AKT/mTOR pathway and Schistosomiasis Japonica infection and hepatic fibrosis.

Infection, Genetics and Evolution, 2020
INTRODUCTION Increasing evidence shows that the PI3K/AKT/mTOR pathway can be activated by a variety of stimulus in immune cells. Schistosomiasis Japonica is a serious threat to human health in some lakes of China.
Qin Xiao, Hai-Bing Yu, Xiao Zhu
semanticscholar   +1 more source

Spatial organization of gene expression: the active chromatin hub

Chromosome Research, 2003
Developmental and tissue-specific expression of higher eukaryotic genes involves activation of transcription at the appropriate time and place and keeping it silent otherwise. Unlike housekeeping genes, tissue-specific genes generally do not cluster on the chromosomes.
de Laat, WL (Wouter), Grosveld, Frank
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Identification of PIGU as the Hub Gene Associated with KRAS Mutation in Colorectal Cancer by Coexpression Analysis

DNA and Cell Biology, 2020
Colorectal cancer (CRC) patients with KRAS mutation are refractory and usually have poor prognosis. We aimed to identify the hub gene associated with KRAS mutant CRCs.
Meng Zhang, Hai-Zhou Wang, Haiou Li, Yun-Jiao Zhou, Ru-yi Peng, Jing Liu, Qiu Zhao   +6 more
semanticscholar   +1 more source