Results 221 to 230 of about 194,990 (329)

Hub genes and common pathogenic mechanisms between COPD and H. pylori infection. [PDF]

J Genet Eng Biotechnol
Li K, Liang T, Li M, Sun X, Xie W, Chen S.   +5 more
europepmc   +1 more source

Image 5_The role of mitochondria-related genes and immune infiltration in carotid atherosclerosis: identification of hub targets through bioinformatics and machine learning approaches.tif

Dan Liu (108669), Kun Guo (283211), Min Li (12799), Xiaochen Yu (3796927), Xue Guan (689652), Xiuru Guan (19739548)   +5 more
openalex   +1 more source

Hepatocyte Mettl3 Deficiency Drives Primary Sclerosing Cholangitis and Liver Fibrosis via Cholangiocyte‐Macrophage Crosstalk

Advanced Science, EarlyView.
Schematic illustration demonstrating that hepatic Mettl3 depletion significantly elevates the secretion of Mif and Csf1. This elevation facilitates Trem2+ macrophage infiltration and triggers cholangiocyte remodeling through the Spp1‐Cd44 interaction, resulting in spontaneous PSC development in vivo.
Wenting Pan, Yuting Yong, Yuanshuai Li, Gaona Shi, Min Zhang, Lingfei Wan, Yue Zhao, Wenling Zhan, Yanli Lin, Qiaozhen Qin, Xupeng Chen, Yanli Ni, Haixu Chen, Wenzai Shi, Xiaomeng Guo, Juan Chen, Shuchen Liu, Youliang Wang, Bing Liu, Xinlong Yan   +19 more
wiley   +1 more source

Immune-related hub genes in intrauterine adhesions: a bioinformatics approach. [PDF]

PeerJ
Lv F, Luo S, Xu F, Du Y, Bai Y, Zhang J, Zou X, Liu D.   +7 more
europepmc   +1 more source

Screening and identification of hub-gene associated with brain metastasis in breast cancer

, 2023
Xiaogang Li, Chao Niu, Ping Lu, Hongwei Wan, Wen-Di Jin, Chunxiao Wang, Wenyuan Mao, Zhiping Zhang, Wanfu Zhang, Bo Li   +9 more
openalex   +1 more source

Stress‐Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer

Advanced Science, EarlyView.
Single‐cell sequencing reveals stress‐programmed immune states driving TNFα–TNFR2–mediated Treg activation and therapy resistance in breast cancer, while targeting this axis restores antitumor immunity. ABSTRACT The tumor microenvironment (TME) harbors diverse immune cell states that shape therapeutic outcomes in breast cancer.
Zhibo Shao, Xuliren Wang, Han Zhu, Ling Yao, Qi Zhang, Zihan Zhai, Xinyi Lv, Xinyuan Xia, Yi Zhang, Xinya Lu, Xinyi Quan, Jiawen Yang, Xinwei Li, Jieyi Dong, Zhi‐ming Shao, Ruoxi Wang, Bingqiu Xiu, Jiong Wu, Sheng Chen   +18 more
wiley   +1 more source

Identification and functional analysis of hub genes in knee osteoarthritis via bioinformatics and experimental validation. [PDF]

Front Bioinform
Jiang S, Cao J, Lu J, Liang J, Li L, Song Y, Gao J, Jiang B.   +7 more
europepmc   +1 more source

Table 2_Identification of common hub genes and construction of immune regulatory networks in aplastic anemia, myelodysplastic syndromes, and acute myeloid leukemia.xlsx

Mingliang Shan (20538920), Li Xu (108702), Wenzhe Yang (11566230), Lili Sui (3621431), Ping Sun (59933), Xiumei Zhuo (20323542), Shiguo Liu (180495)   +6 more
openalex   +1 more source

WDR5‐H3K4me3 Epigenetic Axis Promotes TRMT6‐Dependent tRNA M1A Modification to Facilitate Triple‐Negative Breast Cancer Progression by Suppressing Ferroptosis

Advanced Science, EarlyView.
Upregulated TRMT6 forms aberrant hypermethylation of a specific tRNA pool and serves as a predictor of poor prognosis in TNBC. This m1A modification in tRNAs enhances translation of FTH1 and FTL, reducing the pool of bioavailable Fe2⁺. Reduced Fe2+ availability impairs RSL3‐induced lipid peroxidation and tumor progression.
Yuqing Lei, Xue Wang, Jiahe Liu, Zixu Niu, Jiaqi Hua, Qian Guo, Dan Du, Yuanchang Zhu, Fucheng He, Mingxia Zhou, Hongle Li, Jing He, Jun Li   +12 more
wiley   +1 more source

The analysis reveals novel hub genes and pathways associated with Tetralogy of Fallot. [PDF]

Front Cardiovasc Med
Wen H, Huang Z, Mao Y, Tian W, Peng L, Chen Y.   +5 more
europepmc   +1 more source