Results 91 to 100 of about 1,230,484 (264)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Comparative anthropomorphism and affective valence shape role perception and relational behaviours in human-pet dyads in Romania

Frontiers in Psychology
This study examines the association between attitudes toward animals, anthropomorphic tendencies, and beliefs about the social role of companion animals (cats and dogs) in the household.
Florina Ileana Hica, Florina Ileana Hica, Alina Simona Rusu, Iulia Francesca Pop, Ionel Papuc   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A User Study Evaluation of Predictive Formal Modelling at Runtime in Human-Swarm Interaction

Formal Modelling is often used as part of the design and testing process of software development to ensure that components operate within suitable bounds even in unexpected circumstances.
Sevegnani, Michele, Soorati, Mohammad, Ramchurn, Sarvapali D., Archibald, B., Schneiders, Eike, Sevegnani, M., Hunt, W., Fischer, Joel E., Fishcer, Joel E., Soorati, Mohammad D., Hunt, William, Schneiders, E., Abioye, Ayodeji O., Archibald, Blair, Naiseh, Mohammad, Soorati, M. D., Gu, Yue, Abioye, A. O., Gu, Y., Ramchurn, S. D., Fischer, J. E.   +20 more
core   +1 more source

Regional genetic diversity of bovine viral diarrhea virus in Ethiopia urban and peri-urban dairy farms

Scientific Reports
Bovine viral diarrhea (BVD) is a highly impactful disease in the cattle industry worldwide. The disease is caused by the Bovine Viral Diarrhea Virus (BVDV), a member of the genus Pestivirus within the Flaviviridae family.
Asamenew Tesfaye, Tesfaye Sisay Tessema, Ashenif Simachew, Demessa Negessu, Abde Aliy, Jan Paeshuyse   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Epidemiology of BVD and persistently infected cattle across urban and peri-urban dairy farms in central, northern, and southern parts of Ethiopia

BMC Veterinary Research
Background Bovine viral diarrhea (BVD) is an economically significant disease affecting both domestic and wild ruminant species. The causative agent is bovine viral diarrhea virus (BVDV) of the genus Pestivirus within the family Flaviviridae. In Ethiopia,
Asamenew Tesfaye Melkamsew, Tesfaye Sisay Tessema, Abebe Garoma, Jan Paeshuyse   +3 more
doaj   +1 more source