Results 111 to 120 of about 1,230,484 (264)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Dog–human behavioral synchronization : family dogs synchronize their behavior with child family members

Research on dog social cognition has received widespread attention. However, the vast majority of this research has focused on dogs’ relationships and responsiveness towards adult humans. While little research has considered dog–child interactions from a
MacDonald, Megan, Wanser, Shelby H., Udell, Monique A. R.   +2 more
core  

Human-computer interaction.

, 2012
Human-Computer Interaction: An Empirical Research Perspective is the definitive guide to empirical research in HCI. The book begins with foundational topics including an historical context, the human factor, interaction elements, and the fundamentals of ...
MacKenzie, I. Scott.
core  

Designing for Conversational Interaction with Interactive Dance Works [PDF]

, 2011
In this paper we describe ongoing work, which explores the physicality of human-computer interaction in dance works. The use of physical simulations in the interface to connect with the performers and audiences lived experience of the physical world is ...
CLARKSON, D, Johnston, AJ
core  

Evaluating Co-located Games as a Mediator for Children's Collaborative Interaction

, 2020
In this paper, we investigate different types of collaborative interaction that children in special education may engage in when playing co-located collaborative games. The work used a qualitative approach for studying three different games (2 digital, 1
Wolmet Barendregt, Eriksson, Eva,, Björk, Staffan,, Baykal, Gökçe Elif, Torgersson, Olof,, Eva Eriksson, Torgersson, Olof, Gökçe Elif Baykal, Barendregt, Wolmet, Staffan Bjork, Eriksson, Eva, Barendregt, Wolmet; id_orcid, Bjork, Staffan, Olof Torgersson   +13 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

CRISPR-Cas12/Cas13: Bibliometric analysis and systematic review of its application in infectious disease detection

Journal of Infection and Public Health
Background: Infectious diseases impose a significant burden on the global public health and economy, resulting in an estimated 15 million deaths out of 57 million annually worldwide.
Samson Leta, Tesfaye Rufael Chibssa, Jan Paeshuyse   +2 more
doaj   +1 more source

Human-Animal Interaction and Perinatal Mental Health: A Narrative Review of Selected Literature and Call for Research. [PDF]

Int J Environ Res Public Health, 2021
McDonald SE, McDonald SE, Tomlinson CA, Applebaum JW, Moyer SW, Brown SM, Carter S, Kinser PA.   +7 more
europepmc   +1 more source