Results 121 to 130 of about 1,230,484 (264)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Following the animal : Place, space and literature

, 2018
"Nonhuman animals are ubiquitous to our 'human' societies. Interdisciplinary human/animal research has - for 50 years - drawn attention to how animals are ever-present in what we think of as human spaces and cultures. Our societies are built with animals
Lönngren, Ann-Sofie,
core  

Swimming the channels: An analysis of online archival reference enquiries

Archives of historical and cultural data, such as the UK’s National Archives, receive huge volumes of enquiries from users. These have been seldom systematically studied, despite the obvious benefits to the organisations concerned and interaction ...

core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Equine Assisted Social Work as a mean for authentic relations between clients and staff

, 2014
The purpose of this study was to explore, by qualitative methods, the meaning of equine-assisted social work (EASW) both to young women with self-harm problems and their staff in residential treatment.
Ranta Nilsson, Daniel, Traeen, Bente, Carlsson, Catharina   +2 more
core   +1 more source

Is Dog Owner Obesity a Risk Factor for Canine Obesity? A "One-Health" Study on Human-Animal Interaction in a Region with a High Prevalence of Obesity. [PDF]

Vet Sci, 2022
Suarez L, Bautista-Castaño I, Peña Romera C, Montoya-Alonso JA, Corbera JA.   +4 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Animal welfare, agency, and animal-computer interaction [PDF]

Recent discussions in animal welfare have emphasised the importance of animal agency—the ability of animals to make choices and exert control over their environment in a way that aligns with their needs and preferences.
Heather Browning, Browning, Heather, Walter Veit, Veit, Walter   +3 more
core   +1 more source

The uncanny valley effect and immune activation in virtual reality

Scientific Reports
The uncanny valley effect describes a phenomenon where humanoid, almost lifelike virtual agents evoke feelings of discomfort in the observers. The Pathogen Avoidance Hypothesis proposes that these feelings are based on a cognitive mechanism that ...
Esther K. Diekhof, Svenja Kastner, Donna Deinert, Monika Foerster, Frank Steinicke   +4 more
doaj   +1 more source