Results 161 to 170 of about 12,981,558 (250)

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Human-animal interaction and One Health: establishment and validation of the Brazilian version of the Animal Empathy Scale. [PDF]

Einstein (Sao Paulo)
Savieto RM, Oliveira LPG, Borba GB, Victor EDS, Bomfim SB, de Oliveira LB, Catissi G, Patrício KP, Kiriyama EJ, Leão ER.   +9 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Intersubjectivity as an analytical concept to study human-animal interaction in historical context: street dogs in Late Ottoman period. [PDF]

Front Sociol
Taşdizen B, Yetiş EÖ, Bakırlıoğlu Y.   +2 more
europepmc   +1 more source

Human-Animal Interaction and Older Adults: An Overview. [PDF]

Front Psychol, 2017
Gee NR, Mueller MK, Curl AL.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Corrigendum: Study on adolescents' attitudes and attachment toward companion animals: mitigating the negative effects of cultural estrangement on wellbeing

Frontiers in Psychology
Hikari Koyasu, Sakura Ogasawara, Takefumi Kikusui, Toshiya Murai, Atsushi Nishida, Miho Nagasawa   +5 more
doaj   +1 more source

A Special Relationship-Aspects of Human-Animal Interaction in Birds of Prey, Brown Bears, Beavers, and Elk in Prehistoric Europe. [PDF]

Animals (Basel)
Schmölcke U, Grimm O.
europepmc   +1 more source

An adjunctive human-animal interaction intervention for veterans with PTSD: study protocol for a randomized controlled trial. [PDF]

Trials, 2019
Grubaugh AL, Myers US, Keller SM, Wangelin BC, Lozano BE, Tuerk PW.   +5 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source