Results 171 to 180 of about 1,230,484 (264)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Intersubjectivity as an analytical concept to study human-animal interaction in historical context: street dogs in Late Ottoman period. [PDF]

Front Sociol
Taşdizen B, Yetiş EÖ, Bakırlıoğlu Y.   +2 more
europepmc   +1 more source

Human-Animal Interaction and Older Adults: An Overview. [PDF]

Front Psychol, 2017
Gee NR, Mueller MK, Curl AL.
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Corrigendum: Study on adolescents' attitudes and attachment toward companion animals: mitigating the negative effects of cultural estrangement on wellbeing

Frontiers in Psychology
Hikari Koyasu, Sakura Ogasawara, Takefumi Kikusui, Toshiya Murai, Atsushi Nishida, Miho Nagasawa   +5 more
doaj   +1 more source

A Special Relationship-Aspects of Human-Animal Interaction in Birds of Prey, Brown Bears, Beavers, and Elk in Prehistoric Europe. [PDF]

Animals (Basel)
Schmölcke U, Grimm O.
europepmc   +1 more source

An adjunctive human-animal interaction intervention for veterans with PTSD: study protocol for a randomized controlled trial. [PDF]

Trials, 2019
Grubaugh AL, Myers US, Keller SM, Wangelin BC, Lozano BE, Tuerk PW.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Artificial Neural Network (ANN) as a Tool to Reduce Human-Animal Interaction Improves Senegalese Sole Production. [PDF]

Biomolecules, 2019
Martínez-Vázquez JM, Valcarce DG, Riesco MF, Sanz Marco V, Matsuoka M, Robles V.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source