Results 41 to 50 of about 34,480 (219)

Biomechanical and Physiological Evaluation of Biologically-Inspired Hip Assistance With Belt-Type Soft Exosuits

IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2022
Hip-assisted soft exosuits have been reported for their effect on reducing the metabolic power of human walking. Currently, most studies focus on uni-directional assistance (HF: hip flexion, or HE: hip extension). This paper investigates the effect of bi-
Qiang Chen, Shijie Guo, Jing Wang, Jiaxin Wang, Dan Zhang, Shanhai Jin   +5 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A recurrent reinforcement learning approach applicable to highly uncertain environments

International Journal of Advanced Robotic Systems, 2020
Reinforcement learning has been a promising approach in control and robotics since data-driven learning leads to non-necessity of engineering knowledge. However, it usually requires many interactions with environments to train a controller.
Yang Li, Shijie Guo, Lishuang Zhu, Toshiharu Mukai, Zhongxue Gan   +4 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Child-Centric Robot Dialogue Systems: Fine-Tuning Large Language Models for Better Utterance Understanding and Interaction

Sensors
Dialogue systems must understand children’s utterance intentions by considering their unique linguistic characteristics, such as syntactic incompleteness, pronunciation inaccuracies, and creative expressions, to enable natural conversational engagement ...
Da-Young Kim, Hyo Jeong Lym, Hanna Lee, Ye Jun Lee, Juhyun Kim, Min-Gyu Kim, Yunju Baek   +6 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Producing unexpected emotional expressions in others reduces one’s own agency

Scientific Reports
The sense of agency (SoA), or the subjective feeling of causing and controlling action outcomes, is fundamental to how we engage with the world. In the present study, we investigated how SoA is influenced when individuals unintentionally elicit emotional
Ilkay Ari, Davide De Tommaso, Agnieszka Wykowska   +2 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source