Results 71 to 80 of about 3,603,331 (295)

Human interaction: Dissipative structure and will to power

Revista de Ciencias Sociales
The main theme of this work is the relationship between entropy and the concept of the will to power, aiming to offer a perspective on the transformation of reality based on the relationship between science and philosophy.
Juan Fernando Montoya Carvajal, Luis Fernando Garcés Giraldo, Conrado de Jesús Giraldo   +2 more
doaj   +1 more source

Energy Dissipation from Vibrating Floor Slabs due to Human-Structure Interaction

Shock and Vibration, 2001
Lightweight pre-cast flooring systems using post-tensioning to increase strength but not stiffness are increasingly popular, and vibration serviceability problems tend to govern design of such floors where human occupants are increasingly concerned with ...
James M.W. Brownjohn
doaj   +1 more source

Stochastic transition model for pedestrian dynamics

, 2012
The proposed stochastic model for pedestrian dynamics is based on existing approaches using cellular automata, combined with substantial extensions, to compensate the deficiencies resulting of the discrete grid structure.
Schultz, Michael
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Mpox Insights: From Structure to Human Cell Interaction

Journal of Molecular Pathology
Mpox, a zoonotic viral disease, has emerged as a global concern due to outbreaks in both endemic and non-endemic regions in 2022. Rodents, including African squirrels and Gambian pouched rats, are suspected key reservoirs, with human infections occurring
Md S. Zaman, Robert C. Sizemore, Draven Rodriguez, Emilio Lopez, S. M. Golam Alam, Suleyman Tufa, Juan C. Lopez-Alvarenga, Nuraly S. Akimbekov, Mohammed S. Razzaque   +8 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Integrating feedback control for improved human-structure interaction analysis

Frontiers in Built Environment
The human body, composed of interconnected subsystems with complex dynamic behavior, is often oversimplified or neglected by structural designers and building codes. Human-induced loads, whether passive (e.g., standing, sitting) or active (e.g., walking,
Santiago A. Lopez, Daniel Gomez, Albert R. Ortiz, Sandra Villamizar   +3 more
doaj   +1 more source

Interaction of Cholesterol With the Human SLC1A5 (ASCT2): Insights Into Structure/Function Relationships

Frontiers in Molecular Biosciences, 2019
The human SLC1A5 commonly known as ASCT2 is a sodium-dependent neutral amino acid antiporter involved in transmembrane traffic of glutamine that is exchanged through the cell membrane with smaller amino acids such as serine or threonine.
Mariafrancesca Scalise, Lorena Pochini, Jessica Cosco, Emma Aloe, Tiziano Mazza, Lara Console, Antonella Esposito, Cesare Indiveri   +7 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source