Results 61 to 70 of about 503,408 (307)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Is There a Correlation Between Dog Obesity and Human Obesity? Preliminary Findings of Overweight Status Among Dog Owners and Their Dogs

Frontiers in Veterinary Science, 2021
Background and Aim: Obesity is a serious health issue in people and their pets, with a need for innovative and engaging prevention strategies. One possible strategy is a One Health approach incorporating dogs into prevention programs; however, little ...
Deborah E. Linder, Deborah E. Linder, Sasha Santiago, Eli D. Halbreich   +3 more
doaj   +1 more source

The Bond Between a Horse and a Human [PDF]

, 2009
The bond that exists between a horse and human was examined using EEG from the horse and human simultaneously. Three volunteers ranging from novice to elite horse experience participated with an unfamiliar horse.
Debbie Crews
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Does owning a pet protect older people against loneliness? [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.Pet ownership is thought to make a positive contribution to health, health behaviours and the general well-being of older people. More specifically pet ownership is often
A Gilbey, A Steptoe, AL Podberscek, Ann Bowling, AP Dickens, B Headey, BWJH Penninx, C Victor, C Victor, C Victor, C Victor, C Victor, CB Zhong, Christina Victor, CM Guest, CM Masi, CM Perissinotto, D Melzer, D Russel, DL Wells, E Friedmann, FV Wenz, GC Wenger, H Miltiades, IH Stanley, J Bowlby, J Flaherty, J Hippisley-Coc, J Holt-Lunstad, J McNicholas, J McNicholas, JA Udell, Jitka Pikhartova, JM Siegel, JT Cacioppo, JT Cacioppo, L Andersson, LA Peplau, LB Jennings, M Cattan, M Cattan, M Choi, M Kanamori, M Pinquart, MB Holbrook, MI Wallhagen, MM Herrald, MR Banks, MR Banks, N Savikko, NE Mahon, NM Antonacopoulos, P Demakakos, P Raina, R Hagan, RA Findlay, RA Parslow, RB Olsen, RC Thurston, RF Baumeister, RF Gillum, RS Lazarus, RS Wilson, S Borys, T Fokkema, T Tamura, TF Garrity, The European Pet Food Industry, V Burholt   +68 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Canine Caregivers: Paradoxical Challenges and Rewards

Animals, 2022
Companion dogs are increasingly popular, 38.4% of households in the United States include at least one dog. There are numerous benefits to sharing one’s home with a dog, but because they age more rapidly than people and have shorter lifespans, acquiring ...
Lori R. Kogan, Jean E. Wallace, Peter W. Hellyer, Eloise C. J. Carr   +3 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Trans unsaturated fatty acids : a study of methodology and levels in New Zealand food fats including milkfat : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Biochemistry at Massey University, New Zealand [PDF]

, 1997
Trans fatty acids (TFAs) occur naturally in small amounts in foods such as milk, butter and tallow as a result of biohydrogenation by ruminant gut microflora. They are formed in much larger quantities during chemical hydrogenation of fats and oils.
Fong, Bertram Ian Yin
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source