Results 71 to 80 of about 13,632,971 (306)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Motion-based user identification across XR and metaverse applications by deep classification and similarity learning

Frontiers in Virtual Reality
This paper examines the generalization capacity of two state-of-the-art classification and similarity learning models in reliably identifying users from their motion patterns across diverse eXtended Reality (XR) applications. We introduce a novel dataset
Lukas Schach, Christian Rack, Ryan P. McMahan, Marc Erich Latoschik   +3 more
doaj   +1 more source

Iterative Design and Evaluation of a Tangible Robot-Assisted Handwriting Activity for Special Education

Frontiers in Robotics and AI, 2020
In this article we investigate the role of interactive haptic-enabled tangible robots in supporting the learning of cursive letter writing for children with attention and visuomotor coordination issues.
Arzu Guneysu Ozgur, Ayberk Özgür, Thibault Asselborn, Wafa Johal, Elmira Yadollahi, Barbara Bruno, Barbara Bruno, Melissa Skweres, Pierre Dillenbourg   +8 more
doaj   +1 more source

Give the people what they want: studying end-user needs for enhancing the web [PDF]

PeerJ Computer Science, 2016
End-user programming (EUP) is a common approach for helping ordinary people create small programs for their professional or daily tasks. Since end-users may not have programming skills or strong motivation for learning them, tools should provide what end-
Tak Yeon Lee, Benjamin B. Bederson
doaj   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Improving Pilot Situational Awareness Using a Gaze-Based Assisted Adaptive Interface

Engineering Proceedings
Modern flight decks incorporate advanced automation and real-time data systems to improve safety and efficiency. However, maintaining situational awareness under a high workload remains a critical challenge, particularly when attentional resources are ...
Eleftheria Lito Michanetzi, Angelos Fotopoulos, Dimosthenis Minas, Michalis Xenos   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A review of the empirical studies of computer supported human-to-human communication [PDF]

, 2008
This paper presents a review of the empirical studies of human-to-human communication which have been carried out over the last three decades. Although this review is primarily concerned with the empirical studies of computer supported human-to-human ...
Masoodian, Masood
core  

How deep is your trust? A comparative user requirements’ analysis of automation in medical and mobility technologies

Humanities & Social Sciences Communications
In a changing world full of innovative technologies, trust and trust requirements are increasingly important for designing user-centred systems and ensuring their long-term implementation.
Sophia Hick, Hannah Biermann, Martina Ziefle   +2 more
doaj   +1 more source