Results 81 to 90 of about 1,768,799 (274)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Eye-to-eye or face-to-face? Face and head substitution for co-located augmented reality

Frontiers in Virtual Reality
In co-located extended reality (XR) experiences, headsets occlude their wearers’ facial expressions, impeding natural conversation. We introduce two techniques to mitigate this using off-the-shelf hardware: compositing a view of a personalized avatar ...
Peter Kullmann, Theresa Schell, Mario Botsch, Marc Erich Latoschik   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Tailored information on alternative fuels: Segmenting future consumers' preferences for information and communication related to alternative fuels

Fuel Communications
Increasing emissions in the mobility sector pose a significant challenge for modern society, contributing extensively to climate change. One promising approach to mitigating these emissions is the development of CO₂-based alternative fuels, which can ...
Julia Offermann, Linda Engelmann, Martina Ziefle   +2 more
doaj   +1 more source

Towards Simulating Humans in Augmented Multi-party Interaction [PDF]

, 2005
Human-computer interaction requires modeling of the user. A user profile typically contains preferences, interests, characteristics, and interaction behavior.
Nijholt, Anton
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evaluating Rich Visual Feedback on Head-Up Displays for In-Vehicle Voice Assistants: A User Study

Multimodal Technologies and Interaction
In-vehicle voice assistants face usability challenges due to limitations in delivering feedback within the constraints of the driving environment. The presented study explores the potential of Rich Visual Feedback (RVF) on Head-Up Displays (HUDs) as a ...
Mahmoud Baghdadi, Dilara Samad-Zada, Achim Ebert   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Human Factors Considerations in System Design [PDF]

Human factors considerations in systems design was examined. Human factors in automated command and control, in the efficiency of the human computer interface and system effectiveness are outlined.
Mitchell, C. M., Moe, K. L., Vanbalen, P. M.   +2 more
core   +1 more source