Results 81 to 90 of about 1,765,540 (254)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Human-computer interaction as science [PDF]
, 2015 Human-computer interaction (HCI) has had a long and troublesome relationship to the role of 'science'. HCI's status as an academic object in terms of coherence and adequacy is often in question---leading to desires for establishing a true scientific ...
Reeves, Stuart
core +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Personalized Visualization of the Gestures of Parkinson’s Disease Patients with Virtual Reality
Future InternetParkinson’s disease is a neurological disorder characterized by motor and non-motor symptoms. Assessment methods, despite the many years of existence of the disease, lack individualized visualization. On the other hand, virtual reality promises immersion
Konstantinos Sakkas +6 more
doaj +1 more source
Dislocated Boardgames: Design Potentials for Remote Tangible Play
Multimodal Technologies and Interaction, 2019 Conventional digital and remote forms of play lack the physicality associated with analog play. Research on the materiality of boardgames has highlighted the inherent material aspects to this analog form of play and how these are relevant for the design ...
Bernhard Maurer, Verena Fuchsberger
doaj +1 more source
Towards Simulating Humans in Augmented Multi-party Interaction [PDF]
, 2005 Human-computer interaction requires modeling of the user. A user profile typically contains preferences, interests, characteristics, and interaction behavior.
Nijholt, Anton
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Human/computer control of undersea teleoperators [PDF]
, 1978 The potential of supervisory controlled teleoperators for accomplishment of manipulation and sensory tasks in deep ocean environments is discussed. Teleoperators and supervisory control are defined, the current problems of human divers are reviewed, and ...
Brooks, T. L. +2 more
core +1 more source
On human motion prediction using recurrent neural networks
, 2017 Human motion modelling is a classical problem at the intersection of graphics and computer vision, with applications spanning human-computer interaction, motion synthesis, and motion prediction for virtual and augmented reality.
Black, Michael J. +2 more
core +1 more source