Results 101 to 110 of about 19,334 (259)

Human-likeness of antibody biologics determined by back-translation and comparison with large antibody variable gene repertoires. [PDF]

MAbs, 2020
Schmitz S, Soto C, Crowe JE, Meiler J.
europepmc   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Principles of Human-like Conscious Machine

We propose a simple interpretation of phenomenal consciousness, or qualia, in which qualia are merely grouped signals that represent objects. To establish this interpretation, we first propose criteria for determining whether a machine can possess qualia.
Fangfang Li, Xiaojie Zhang
openaire   +2 more sources

On Benchmarking Human-Like Intelligence in Machines

CoRR
18 pages, 5 ...
Lance Ying, Katherine M. Collins, Lionel Wong, Ilia Sucholutsky, Ryan Liu 0001, Adrian Weller, Tianmin Shu, Thomas L. Griffiths 0001, Joshua B. Tenenbaum   +8 more
openaire   +2 more sources

Reputation through artificial intelligence? On the effectiveness of virtual influencers as spokespersons in corporate crisis communication

Frontiers in Communication
With virtual social media influencers, a new form of brand ambassador has established itself on social networks. In our study, we look at the extent to which they are also suitable as spokespersons after a corporate crisis.
Zoe Olbermann, Magdalena Nagl
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Uncanny valley effect: Research on the impact of digital human appearance on learners in a multi-agent collaborative learning environment

Educational Technology & Society
The integration of large language models and digital humans in multi-agent collaborative learning creates tension between technological advancement and human-centered design.
Jian Liao, Hui Li, Yaping Zuo, Linrong Zhong, Ming Liu, Tao Xie and Geping Liu
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source