Results 111 to 120 of about 23,617 (297)

The humanism in the thought and in the spirituality of saint Bernard of Clairvaux: The fundamental attitude discovered in cistercian mystics and cistercian art

The Person and the Challenges
This paper is dedicated to humanism in the thought, spirituality and teaching of Saint Bernard. Bernard’s way of thinking and his spiritual, interior life were the object of study by many scholars.
Dariusz Tabor
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

GOD'S IMAGE AND LIKENESS IN HUMANS AND OTHER ANIMALS: PERFORMATIVE SOUL‐MAKING AND GRACED NATURE

Zygon, 2012
Although official Roman Catholic teaching affirms the concept of evolution as a convincing theory in order to explain the biological origin of different life forms, there is still a strong insistence on an “ontological gap” between human beings and all ...
doaj   +2 more sources

Playing Pairs with Pepper

, 2018
As robots become increasingly prevalent in almost all areas of society, the factors affecting humans trust in those robots becomes increasingly important.
Lohan, Katrin, Yaseen, Abdelrahman
core  

Affect and believability in game characters:a review of the use of affective computing in games [PDF]

, 2017
Virtual agents are important in many digital environments. Designing a character that highly engages users in terms of interaction is an intricate task constrained by many requirements.
ElSayed, Salma, King, David J.
core  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Reputation through artificial intelligence? On the effectiveness of virtual influencers as spokespersons in corporate crisis communication

Frontiers in Communication
With virtual social media influencers, a new form of brand ambassador has established itself on social networks. In our study, we look at the extent to which they are also suitable as spokespersons after a corporate crisis.
Zoe Olbermann, Magdalena Nagl
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Understanding How AI Chatbots Influence EFL Learners’ Oral English Learning Motivation and Outcomes: Evidence From Chinese Learners

IEEE Access
Artificial intelligence is undergoing rapid transformations, and its application in education has gradually expanded. In particular, the educational effect of artificial intelligence chatbots in English learning has steadily become prominent.
Wenbo Wei, An Zhao, Hongning Ma
doaj   +1 more source