Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Multi-omics analysis: Gut microbial metabolites in ovarian lesions. [PDF]
J Int Med ResYinghong L, Xiaojuan Y, Xiaojuan Y.
europepmc +1 more source
Design and Antischizophrenic Studies of 1,3-disubstituted Chalcone Derivatives: <i>In-silico</i> Molecular Docking Approach. [PDF]
Trop Life Sci ResZubair AO +4 more
europepmc +1 more source
The potential mechanism and immunomodulatory effect of gut microbiota-derived metabolites in the treatment of gastric cancer by integrating network pharmacology and molecular docking. [PDF]
Clin Exp MedChen Y +5 more
europepmc +1 more source
Context-dependent cytotoxicity and ADMET profiling of methoxylated flavonoids as novel leads for metastatic prostate cancer. [PDF]
RSC AdvHourani W.
europepmc +1 more source
Computational Identification of Potent Multitarget Natural Ligands for Alzheimer's Disease Therapeutics. [PDF]
Scientifica (Cairo)Sharif N +10 more
europepmc +1 more source